
Glutamine Metabolism in Cancer: Understanding the Heterogeneity.
Reliance on glutamine has long been considered a hallmark of cancer cell metabolism. However, some recent studies have challenged this notion in vivo, prompting a need for further clarifications on the role of glutamine metabolism in cancer. We find that there is ample evidence of an essential role for glutamine in tumors and that a variety of factors, including tissue type, the underlying cancer genetics, the tumor microenvironment and other variables such as diet and host physiology collectively influence the role of glutamine in cancer. Thus the requirements for glutamine in cancer are overall highly heterogeneous. In this review, we discuss the implications both for basic science and for targeting glutamine metabolism in cancer therapy.
Duke Scholars
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Related Subject Headings
- Neoplasms
- Molecular Targeted Therapy
- Humans
- Glutamine
- Glutaminase
- 3211 Oncology and carcinogenesis
- 1112 Oncology and Carcinogenesis
Citation

Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Neoplasms
- Molecular Targeted Therapy
- Humans
- Glutamine
- Glutaminase
- 3211 Oncology and carcinogenesis
- 1112 Oncology and Carcinogenesis