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Glutamine Metabolism in Cancer: Understanding the Heterogeneity.

Publication ,  Journal Article
Cluntun, AA; Lukey, MJ; Cerione, RA; Locasale, JW
Published in: Trends Cancer
March 2017

Reliance on glutamine has long been considered a hallmark of cancer cell metabolism. However, some recent studies have challenged this notion in vivo, prompting a need for further clarifications on the role of glutamine metabolism in cancer. We find that there is ample evidence of an essential role for glutamine in tumors and that a variety of factors, including tissue type, the underlying cancer genetics, the tumor microenvironment and other variables such as diet and host physiology collectively influence the role of glutamine in cancer. Thus the requirements for glutamine in cancer are overall highly heterogeneous. In this review, we discuss the implications both for basic science and for targeting glutamine metabolism in cancer therapy.

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Published In

Trends Cancer

DOI

ISSN

2405-8033

Publication Date

March 2017

Volume

3

Issue

3

Start / End Page

169 / 180

Location

United States

Related Subject Headings

  • Neoplasms
  • Molecular Targeted Therapy
  • Humans
  • Glutamine
  • Glutaminase
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

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Cluntun, A. A., Lukey, M. J., Cerione, R. A., & Locasale, J. W. (2017). Glutamine Metabolism in Cancer: Understanding the Heterogeneity. Trends Cancer, 3(3), 169–180. https://doi.org/10.1016/j.trecan.2017.01.005
Cluntun, Ahmad A., Michael J. Lukey, Richard A. Cerione, and Jason W. Locasale. “Glutamine Metabolism in Cancer: Understanding the Heterogeneity.Trends Cancer 3, no. 3 (March 2017): 169–80. https://doi.org/10.1016/j.trecan.2017.01.005.
Cluntun AA, Lukey MJ, Cerione RA, Locasale JW. Glutamine Metabolism in Cancer: Understanding the Heterogeneity. Trends Cancer. 2017 Mar;3(3):169–80.
Cluntun, Ahmad A., et al. “Glutamine Metabolism in Cancer: Understanding the Heterogeneity.Trends Cancer, vol. 3, no. 3, Mar. 2017, pp. 169–80. Pubmed, doi:10.1016/j.trecan.2017.01.005.
Cluntun AA, Lukey MJ, Cerione RA, Locasale JW. Glutamine Metabolism in Cancer: Understanding the Heterogeneity. Trends Cancer. 2017 Mar;3(3):169–180.
Journal cover image

Published In

Trends Cancer

DOI

ISSN

2405-8033

Publication Date

March 2017

Volume

3

Issue

3

Start / End Page

169 / 180

Location

United States

Related Subject Headings

  • Neoplasms
  • Molecular Targeted Therapy
  • Humans
  • Glutamine
  • Glutaminase
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis