Skip to main content

Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer.

Publication ,  Journal Article
Singhal, S; Bhojnagarwala, PS; O'Brien, S; Moon, EK; Garfall, AL; Rao, AS; Quatromoni, JG; Stephen, TL; Litzky, L; Deshpande, C; Feldman, MD ...
Published in: Cancer Cell
July 11, 2016

Based on studies in mouse tumor models, granulocytes appear to play a tumor-promoting role. However, there are limited data about the phenotype and function of tumor-associated neutrophils (TANs) in humans. Here, we identify a subset of TANs that exhibited characteristics of both neutrophils and antigen-presenting cells (APCs) in early-stage human lung cancer. These APC-like "hybrid neutrophils," which originate from CD11b(+)CD15(hi)CD10(-)CD16(low) immature progenitors, are able to cross-present antigens, as well as trigger and augment anti-tumor T cell responses. Interferon-γ and granulocyte-macrophage colony-stimulating factor are requisite factors in the tumor that, working through the Ikaros transcription factor, synergistically exert their APC-promoting effects on the progenitors. Overall, these data demonstrate the existence of a specialized TAN subset with anti-tumor capabilities in human cancer.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cancer Cell

DOI

EISSN

1878-3686

Publication Date

July 11, 2016

Volume

30

Issue

1

Start / End Page

120 / 135

Location

United States

Related Subject Headings

  • T-Lymphocytes, Cytotoxic
  • Oncology & Carcinogenesis
  • Neutrophils
  • Neoplasm Staging
  • Lung Neoplasms
  • Interferon-gamma
  • Ikaros Transcription Factor
  • Humans
  • Granulocyte-Macrophage Colony-Stimulating Factor
  • Gene Expression Regulation, Neoplastic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Singhal, S., Bhojnagarwala, P. S., O’Brien, S., Moon, E. K., Garfall, A. L., Rao, A. S., … Eruslanov, E. B. (2016). Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer. Cancer Cell, 30(1), 120–135. https://doi.org/10.1016/j.ccell.2016.06.001
Singhal, Sunil, Pratik S. Bhojnagarwala, Shaun O’Brien, Edmund K. Moon, Alfred L. Garfall, Abhishek S. Rao, Jon G. Quatromoni, et al. “Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer.Cancer Cell 30, no. 1 (July 11, 2016): 120–35. https://doi.org/10.1016/j.ccell.2016.06.001.
Singhal S, Bhojnagarwala PS, O’Brien S, Moon EK, Garfall AL, Rao AS, et al. Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer. Cancer Cell. 2016 Jul 11;30(1):120–35.
Singhal, Sunil, et al. “Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer.Cancer Cell, vol. 30, no. 1, July 2016, pp. 120–35. Pubmed, doi:10.1016/j.ccell.2016.06.001.
Singhal S, Bhojnagarwala PS, O’Brien S, Moon EK, Garfall AL, Rao AS, Quatromoni JG, Stephen TL, Litzky L, Deshpande C, Feldman MD, Hancock WW, Conejo-Garcia JR, Albelda SM, Eruslanov EB. Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer. Cancer Cell. 2016 Jul 11;30(1):120–135.

Published In

Cancer Cell

DOI

EISSN

1878-3686

Publication Date

July 11, 2016

Volume

30

Issue

1

Start / End Page

120 / 135

Location

United States

Related Subject Headings

  • T-Lymphocytes, Cytotoxic
  • Oncology & Carcinogenesis
  • Neutrophils
  • Neoplasm Staging
  • Lung Neoplasms
  • Interferon-gamma
  • Ikaros Transcription Factor
  • Humans
  • Granulocyte-Macrophage Colony-Stimulating Factor
  • Gene Expression Regulation, Neoplastic