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Survival, disabilities in activities of daily living, and physical and cognitive functioning among the oldest-old in China: a cohort study.

Publication ,  Journal Article
Zeng, Y; Feng, Q; Hesketh, T; Christensen, K; Vaupel, JW
Published in: Lancet
April 22, 2017

BACKGROUND: The oldest-old (those aged ≥80 years) are the most rapidly growing age group globally, and are most in need of health care and assistance. We aimed to assess changes in mortality, disability in activities of daily living, and physical and cognitive functioning among oldest-old individuals between 1998 and 2008. METHODS: We used data from the Chinese Longitudinal Healthy Longevity Study. Three pairs of cohorts aged 80-89 years, 90-99 years, and 100-105 years (in total, 19 528 oldest-old participants) were examined; the two cohorts in each pair were born 10 years apart, with the same age at the time of the assessment in the 1998 and 2008 surveys. Four health outcomes were investigated: annual death rate, Activities of Daily Living (ADL), physical performance in three tests and cognitive function measured by Mini-Mental State Examination (MMSE). We used different tests and multivariate regression analyses to examine the cohort differences. FINDINGS: Controlling for various confounding factors, we noted that annual mortality among oldest-old individuals was substantially reduced between 0·2% and 1·3% in 1998-2008 compared with individuals of the same age born 10 years previously, and that disability according to activities of daily living had significantly reduced annually between 0·8% and 2·8%. However, cognitive impairment in the later cohorts increased annually between 0·7% and 2·2% and objective physical performance capacity (standing up from a chair, picking up a book from the floor, and turning around 360°) decreased anually between 0·4% and 3·8%. We also noted that female mortality was substantially lower than male mortality among the oldest-old, but that women's functional capacities in activities of daily living, cognition, and physical performance were worse than their male counterparts. INTERPRETATION: Advances in medications, lifestyle, and socioeconomics might compress activities of daily living disability, that is, benefits of success, but lifespan extension might expand disability of physical and cognitive functioning as more frail, elderly individuals survive with health problems, that is, costs of success. FUNDING: National Natural Science Foundation of China, National Institute on Aging/National Institutes of Health, United Nations Funds for Population Activities.

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Published In

Lancet

DOI

EISSN

1474-547X

Publication Date

April 22, 2017

Volume

389

Issue

10079

Start / End Page

1619 / 1629

Location

England

Related Subject Headings

  • Surveys and Questionnaires
  • Psychomotor Performance
  • Male
  • Longitudinal Studies
  • Longevity
  • Humans
  • Geriatric Assessment
  • General & Internal Medicine
  • Female
  • Exercise
 

Citation

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Zeng, Y., Feng, Q., Hesketh, T., Christensen, K., & Vaupel, J. W. (2017). Survival, disabilities in activities of daily living, and physical and cognitive functioning among the oldest-old in China: a cohort study. Lancet, 389(10079), 1619–1629. https://doi.org/10.1016/S0140-6736(17)30548-2
Zeng, Yi, Qiushi Feng, Therese Hesketh, Kaare Christensen, and James W. Vaupel. “Survival, disabilities in activities of daily living, and physical and cognitive functioning among the oldest-old in China: a cohort study.Lancet 389, no. 10079 (April 22, 2017): 1619–29. https://doi.org/10.1016/S0140-6736(17)30548-2.
Zeng Y, Feng Q, Hesketh T, Christensen K, Vaupel JW. Survival, disabilities in activities of daily living, and physical and cognitive functioning among the oldest-old in China: a cohort study. Lancet. 2017 Apr 22;389(10079):1619–29.
Zeng, Yi, et al. “Survival, disabilities in activities of daily living, and physical and cognitive functioning among the oldest-old in China: a cohort study.Lancet, vol. 389, no. 10079, Apr. 2017, pp. 1619–29. Pubmed, doi:10.1016/S0140-6736(17)30548-2.
Zeng Y, Feng Q, Hesketh T, Christensen K, Vaupel JW. Survival, disabilities in activities of daily living, and physical and cognitive functioning among the oldest-old in China: a cohort study. Lancet. 2017 Apr 22;389(10079):1619–1629.

Published In

Lancet

DOI

EISSN

1474-547X

Publication Date

April 22, 2017

Volume

389

Issue

10079

Start / End Page

1619 / 1629

Location

England

Related Subject Headings

  • Surveys and Questionnaires
  • Psychomotor Performance
  • Male
  • Longitudinal Studies
  • Longevity
  • Humans
  • Geriatric Assessment
  • General & Internal Medicine
  • Female
  • Exercise