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Auxin minimum triggers the developmental switch from cell division to cell differentiation in the Arabidopsis root.

Publication ,  Journal Article
Di Mambro, R; De Ruvo, M; Pacifici, E; Salvi, E; Sozzani, R; Benfey, PN; Busch, W; Novak, O; Ljung, K; Di Paola, L; Marée, AFM; Costantino, P ...
Published in: Proceedings of the National Academy of Sciences of the United States of America
September 2017

In multicellular organisms, a stringent control of the transition between cell division and differentiation is crucial for correct tissue and organ development. In the Arabidopsis root, the boundary between dividing and differentiating cells is positioned by the antagonistic interaction of the hormones auxin and cytokinin. Cytokinin affects polar auxin transport, but how this impacts the positional information required to establish this tissue boundary, is still unknown. By combining computational modeling with molecular genetics, we show that boundary formation is dependent on cytokinin's control on auxin polar transport and degradation. The regulation of both processes shapes the auxin profile in a well-defined auxin minimum. This auxin minimum positions the boundary between dividing and differentiating cells, acting as a trigger for this developmental transition, thus controlling meristem size.

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Published In

Proceedings of the National Academy of Sciences of the United States of America

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

September 2017

Volume

114

Issue

36

Start / End Page

E7641 / E7649

Related Subject Headings

  • Signal Transduction
  • Plant Roots
  • Plant Growth Regulators
  • Meristem
  • Indoleacetic Acids
  • Gene Expression Regulation, Plant
  • Cytokinins
  • Cell Division
  • Cell Differentiation
  • Biological Transport
 

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Di Mambro, R., De Ruvo, M., Pacifici, E., Salvi, E., Sozzani, R., Benfey, P. N., … Sabatini, S. (2017). Auxin minimum triggers the developmental switch from cell division to cell differentiation in the Arabidopsis root. Proceedings of the National Academy of Sciences of the United States of America, 114(36), E7641–E7649. https://doi.org/10.1073/pnas.1705833114
Di Mambro, Riccardo, Micol De Ruvo, Elena Pacifici, Elena Salvi, Rosangela Sozzani, Philip N. Benfey, Wolfgang Busch, et al. “Auxin minimum triggers the developmental switch from cell division to cell differentiation in the Arabidopsis root.Proceedings of the National Academy of Sciences of the United States of America 114, no. 36 (September 2017): E7641–49. https://doi.org/10.1073/pnas.1705833114.
Di Mambro R, De Ruvo M, Pacifici E, Salvi E, Sozzani R, Benfey PN, et al. Auxin minimum triggers the developmental switch from cell division to cell differentiation in the Arabidopsis root. Proceedings of the National Academy of Sciences of the United States of America. 2017 Sep;114(36):E7641–9.
Di Mambro, Riccardo, et al. “Auxin minimum triggers the developmental switch from cell division to cell differentiation in the Arabidopsis root.Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 36, Sept. 2017, pp. E7641–49. Epmc, doi:10.1073/pnas.1705833114.
Di Mambro R, De Ruvo M, Pacifici E, Salvi E, Sozzani R, Benfey PN, Busch W, Novak O, Ljung K, Di Paola L, Marée AFM, Costantino P, Grieneisen VA, Sabatini S. Auxin minimum triggers the developmental switch from cell division to cell differentiation in the Arabidopsis root. Proceedings of the National Academy of Sciences of the United States of America. 2017 Sep;114(36):E7641–E7649.
Journal cover image

Published In

Proceedings of the National Academy of Sciences of the United States of America

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

September 2017

Volume

114

Issue

36

Start / End Page

E7641 / E7649

Related Subject Headings

  • Signal Transduction
  • Plant Roots
  • Plant Growth Regulators
  • Meristem
  • Indoleacetic Acids
  • Gene Expression Regulation, Plant
  • Cytokinins
  • Cell Division
  • Cell Differentiation
  • Biological Transport