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Donor-specific cell-based assays in studying sensitivity to low-dose radiation: A population-based perspective

Publication ,  Journal Article
Il'yasova, D; Kinev, A; Melton, CD; Davis, FG
Published in: Frontiers in Public Health
November 18, 2014

Currently, a linear no-threshold model is used to estimate health risks associated with exposure to low-dose radiation, a prevalent exposure in the general population, because the direct estimation from epidemiological studies suffers from uncertainty. This model has been criticized based on unique biology of low-dose radiation. Whether the departure from linearity is toward increased or decreased risk is intensely debated. We present an approach based on individual radiosensitivity testing and discuss how individual radiosensitivity can be assessed with the goal to develop a quantifiable measure of cellular response that can be conducted via high-throughput population testing.

Duke Scholars

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Published In

Frontiers in Public Health

DOI

EISSN

2296-2565

Publication Date

November 18, 2014

Volume

2

Issue

NOV

Related Subject Headings

  • 4206 Public health
  • 4203 Health services and systems
  • 1117 Public Health and Health Services
 

Citation

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Il’yasova, D., Kinev, A., Melton, C. D., & Davis, F. G. (2014). Donor-specific cell-based assays in studying sensitivity to low-dose radiation: A population-based perspective. Frontiers in Public Health, 2(NOV). https://doi.org/10.3389/fpubh.2014.00244
Il’yasova, D., A. Kinev, C. D. Melton, and F. G. Davis. “Donor-specific cell-based assays in studying sensitivity to low-dose radiation: A population-based perspective.” Frontiers in Public Health 2, no. NOV (November 18, 2014). https://doi.org/10.3389/fpubh.2014.00244.
Il’yasova D, Kinev A, Melton CD, Davis FG. Donor-specific cell-based assays in studying sensitivity to low-dose radiation: A population-based perspective. Frontiers in Public Health. 2014 Nov 18;2(NOV).
Il’yasova, D., et al. “Donor-specific cell-based assays in studying sensitivity to low-dose radiation: A population-based perspective.” Frontiers in Public Health, vol. 2, no. NOV, Nov. 2014. Scopus, doi:10.3389/fpubh.2014.00244.
Il’yasova D, Kinev A, Melton CD, Davis FG. Donor-specific cell-based assays in studying sensitivity to low-dose radiation: A population-based perspective. Frontiers in Public Health. 2014 Nov 18;2(NOV).

Published In

Frontiers in Public Health

DOI

EISSN

2296-2565

Publication Date

November 18, 2014

Volume

2

Issue

NOV

Related Subject Headings

  • 4206 Public health
  • 4203 Health services and systems
  • 1117 Public Health and Health Services