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Amniotic membrane use for management of corneal limbal stem cell deficiency.

Publication ,  Journal Article
Sabater, AL; Perez, VL
Published in: Curr Opin Ophthalmol
July 2017

PURPOSE OF REVIEW: The current article reviews the most recent surgical techniques for management of corneal limbal stem cell deficiency (LSCD) using amniotic membrane tissue. RECENT FINDINGS: Early successes with amniotic membrane transplantation (AMT) for the treatment of ocular surface disorders have encouraged clinicians to investigate new applications. The use of AMT as a temporary patch in emergency cases in which LSCD may develop has considerably improved the prognosis of these patients. Amniotic membrane does not have stem cells of its own, but it supports regeneration of limbal epithelial stem cells (LESCs). Similarly, the combination of AMT with classic surgical techniques has enhanced the surgical success rates in most case series. Furthermore, based on its advantageous properties as a cell carrier, new applications to support in-vivo and ex-vivo cell expansion have been reported recently. SUMMARY: LSCD constitutes a general indication for AMT. Based on the clinical scenario, AMT may be performed alone to support regeneration of LESCs, in combination with other surgical techniques, or even supporting the in-vivo or ex-vivo expansion of LESCs.

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Published In

Curr Opin Ophthalmol

DOI

EISSN

1531-7021

Publication Date

July 2017

Volume

28

Issue

4

Start / End Page

363 / 369

Location

United States

Related Subject Headings

  • Stem Cell Transplantation
  • Ophthalmology & Optometry
  • Limbus Corneae
  • Humans
  • Epithelium, Corneal
  • Corneal Diseases
  • Amnion
  • 1113 Opthalmology and Optometry
 

Citation

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Sabater, A. L., & Perez, V. L. (2017). Amniotic membrane use for management of corneal limbal stem cell deficiency. Curr Opin Ophthalmol, 28(4), 363–369. https://doi.org/10.1097/ICU.0000000000000386
Sabater, Alfonso L., and Victor L. Perez. “Amniotic membrane use for management of corneal limbal stem cell deficiency.Curr Opin Ophthalmol 28, no. 4 (July 2017): 363–69. https://doi.org/10.1097/ICU.0000000000000386.
Sabater AL, Perez VL. Amniotic membrane use for management of corneal limbal stem cell deficiency. Curr Opin Ophthalmol. 2017 Jul;28(4):363–9.
Sabater, Alfonso L., and Victor L. Perez. “Amniotic membrane use for management of corneal limbal stem cell deficiency.Curr Opin Ophthalmol, vol. 28, no. 4, July 2017, pp. 363–69. Pubmed, doi:10.1097/ICU.0000000000000386.
Sabater AL, Perez VL. Amniotic membrane use for management of corneal limbal stem cell deficiency. Curr Opin Ophthalmol. 2017 Jul;28(4):363–369.

Published In

Curr Opin Ophthalmol

DOI

EISSN

1531-7021

Publication Date

July 2017

Volume

28

Issue

4

Start / End Page

363 / 369

Location

United States

Related Subject Headings

  • Stem Cell Transplantation
  • Ophthalmology & Optometry
  • Limbus Corneae
  • Humans
  • Epithelium, Corneal
  • Corneal Diseases
  • Amnion
  • 1113 Opthalmology and Optometry