Skip to main content

Amniotic membrane use for management of corneal limbal stem cell deficiency.

Publication ,  Journal Article
Sabater, AL; Perez, VL
Published in: Current opinion in ophthalmology
July 2017

The current article reviews the most recent surgical techniques for management of corneal limbal stem cell deficiency (LSCD) using amniotic membrane tissue.Early successes with amniotic membrane transplantation (AMT) for the treatment of ocular surface disorders have encouraged clinicians to investigate new applications. The use of AMT as a temporary patch in emergency cases in which LSCD may develop has considerably improved the prognosis of these patients. Amniotic membrane does not have stem cells of its own, but it supports regeneration of limbal epithelial stem cells (LESCs). Similarly, the combination of AMT with classic surgical techniques has enhanced the surgical success rates in most case series. Furthermore, based on its advantageous properties as a cell carrier, new applications to support in-vivo and ex-vivo cell expansion have been reported recently.LSCD constitutes a general indication for AMT. Based on the clinical scenario, AMT may be performed alone to support regeneration of LESCs, in combination with other surgical techniques, or even supporting the in-vivo or ex-vivo expansion of LESCs.

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Current opinion in ophthalmology

DOI

EISSN

1531-7021

ISSN

1040-8738

Publication Date

July 2017

Volume

28

Issue

4

Start / End Page

363 / 369

Related Subject Headings

  • Stem Cell Transplantation
  • Ophthalmology & Optometry
  • Limbus Corneae
  • Humans
  • Epithelium, Corneal
  • Corneal Diseases
  • Amnion
  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sabater, A. L., & Perez, V. L. (2017). Amniotic membrane use for management of corneal limbal stem cell deficiency. Current Opinion in Ophthalmology, 28(4), 363–369. https://doi.org/10.1097/icu.0000000000000386
Sabater, Alfonso L., and Victor L. Perez. “Amniotic membrane use for management of corneal limbal stem cell deficiency.Current Opinion in Ophthalmology 28, no. 4 (July 2017): 363–69. https://doi.org/10.1097/icu.0000000000000386.
Sabater AL, Perez VL. Amniotic membrane use for management of corneal limbal stem cell deficiency. Current opinion in ophthalmology. 2017 Jul;28(4):363–9.
Sabater, Alfonso L., and Victor L. Perez. “Amniotic membrane use for management of corneal limbal stem cell deficiency.Current Opinion in Ophthalmology, vol. 28, no. 4, July 2017, pp. 363–69. Epmc, doi:10.1097/icu.0000000000000386.
Sabater AL, Perez VL. Amniotic membrane use for management of corneal limbal stem cell deficiency. Current opinion in ophthalmology. 2017 Jul;28(4):363–369.

Published In

Current opinion in ophthalmology

DOI

EISSN

1531-7021

ISSN

1040-8738

Publication Date

July 2017

Volume

28

Issue

4

Start / End Page

363 / 369

Related Subject Headings

  • Stem Cell Transplantation
  • Ophthalmology & Optometry
  • Limbus Corneae
  • Humans
  • Epithelium, Corneal
  • Corneal Diseases
  • Amnion
  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry