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Role of exosomes in treatment of hepatocellular carcinoma.

Publication ,  Journal Article
Moris, D; Beal, EW; Chakedis, J; Burkhart, RA; Schmidt, C; Dillhoff, M; Zhang, X; Theocharis, S; Pawlik, TM
Published in: Surgical oncology
September 2017

Exosomes are nanovesicles that may play a role in intercellular communication by acting as carriers of functional contents such as proteins, lipids, RNA molecules and circulating DNA from donor to recipient cells. In addition, exosomes may play a potential role in immunosurveillance and tumor pathogenesis and progression. Recently, research has increasingly focused on the role of exosomes in hepatocellular carcinoma (HCC), the most common primary liver malignancy. We herein review data on emerging experimental and clinical studies focused on the role of exosomes in the pathogenesis, diagnosis, progression and chemotherapy response of patients with HCC. Beyond their diagnostic value in HCC, exosomes are involved in different mechanisms of HCC tumor pathogenesis and progression including angiogenesis and immune escape. Moreover, exosomes have been demonstrated to change the tumor microenvironment to a less tolerogenic state, favoring immune response and tumor suppression. These results underline a practical and potentially feasible role of exosomes in the treatment of patients with HCC, both as a target and a vehicle for drug design. Future studies will need to further elucidate the exact role and reliability of exosomes as screening, diagnostic and treatment targets in patients with HCC.

Duke Scholars

Published In

Surgical oncology

DOI

EISSN

1879-3320

ISSN

0960-7404

Publication Date

September 2017

Volume

26

Issue

3

Start / End Page

219 / 228

Related Subject Headings

  • Tumor Microenvironment
  • Oncology & Carcinogenesis
  • Neovascularization, Pathologic
  • Mesenchymal Stem Cells
  • Liver Neoplasms
  • Humans
  • Forecasting
  • Exosomes
  • Drug Resistance, Neoplasm
  • Carcinoma, Hepatocellular
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Moris, D., Beal, E. W., Chakedis, J., Burkhart, R. A., Schmidt, C., Dillhoff, M., … Pawlik, T. M. (2017). Role of exosomes in treatment of hepatocellular carcinoma. Surgical Oncology, 26(3), 219–228. https://doi.org/10.1016/j.suronc.2017.04.005
Moris, Demetrios, Eliza W. Beal, Jeffery Chakedis, Richard A. Burkhart, Carl Schmidt, Mary Dillhoff, Xufeng Zhang, Stamatios Theocharis, and Timothy M. Pawlik. “Role of exosomes in treatment of hepatocellular carcinoma.Surgical Oncology 26, no. 3 (September 2017): 219–28. https://doi.org/10.1016/j.suronc.2017.04.005.
Moris D, Beal EW, Chakedis J, Burkhart RA, Schmidt C, Dillhoff M, et al. Role of exosomes in treatment of hepatocellular carcinoma. Surgical oncology. 2017 Sep;26(3):219–28.
Moris, Demetrios, et al. “Role of exosomes in treatment of hepatocellular carcinoma.Surgical Oncology, vol. 26, no. 3, Sept. 2017, pp. 219–28. Epmc, doi:10.1016/j.suronc.2017.04.005.
Moris D, Beal EW, Chakedis J, Burkhart RA, Schmidt C, Dillhoff M, Zhang X, Theocharis S, Pawlik TM. Role of exosomes in treatment of hepatocellular carcinoma. Surgical oncology. 2017 Sep;26(3):219–228.
Journal cover image

Published In

Surgical oncology

DOI

EISSN

1879-3320

ISSN

0960-7404

Publication Date

September 2017

Volume

26

Issue

3

Start / End Page

219 / 228

Related Subject Headings

  • Tumor Microenvironment
  • Oncology & Carcinogenesis
  • Neovascularization, Pathologic
  • Mesenchymal Stem Cells
  • Liver Neoplasms
  • Humans
  • Forecasting
  • Exosomes
  • Drug Resistance, Neoplasm
  • Carcinoma, Hepatocellular