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Extended hepatectomy using the bipolar tissue sealer: an experimental model of small-for-size syndrome in pigs.

Publication ,  Journal Article
Athanasiou, A; Kontos, M; Pikoulis, E; Griniatsos, J; Papalois, A; Spartalis, E; Moris, D; Felekouras, E; Liakakos, T
Published in: Journal of B.U.ON. : official journal of the Balkan Union of Oncology
November 2016

After liver transplantation with a small-for-size liver graft or after extensive hepatectomy for liver malignancies or other non malignant conditions with an insufficient liver volume, the survival of patients depends on liver regeneration. This study was carried out in order to create a new porcine model for the study of small-for-size syndrome (SFSS) after extensive hepatectomy.In the present study we used 23 domestic Landrace pigs weighing 28.3±3 kg and aged 19-21 weeks. We describe our detailed surgical procedure for 75% partial hepatectomy a in porcine model, using the saline-coupled bipolar sealing device (Aquamantys®) for hepatectomy.The Aquamantis 2.3 bipolar sealer was connected to the Aquamantis generator and was adjusted to produce 150 watts at a medium flow rate of 20 ml/min. The device temperature was programmed to remain at approximately 100° C and, as a consequence, it produced a tissue ablation without charring. The mean operating time was 153.8 min and the mean blood loss 81.9 ml. The estimated residual liver weight (ERL) was 177 g, whereas the mean proportion of ERL was 24.5%. There was no perioperative mortality.A large animal model, such as pig, is extremely useful in order to reproduce and understand the SFSS. Our simple technique for successful resection of 75% of the liver in pigs, using the Aquamantys system, achieves effective and safe liver parenchymal transection with significant decrease of intraoperative blood loss and can provide useful information for researchers.

Duke Scholars

Published In

Journal of B.U.ON. : official journal of the Balkan Union of Oncology

EISSN

2241-6293

ISSN

1107-0625

Publication Date

November 2016

Volume

21

Issue

6

Start / End Page

1403 / 1409

Related Subject Headings

  • Time Factors
  • Sus scrofa
  • Operative Time
  • Oncology & Carcinogenesis
  • Models, Animal
  • Liver Regeneration
  • Liver
  • Hepatectomy
  • Equipment Design
  • Electrocoagulation
 

Citation

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Athanasiou, A., Kontos, M., Pikoulis, E., Griniatsos, J., Papalois, A., Spartalis, E., … Liakakos, T. (2016). Extended hepatectomy using the bipolar tissue sealer: an experimental model of small-for-size syndrome in pigs. Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology, 21(6), 1403–1409.
Athanasiou, Antonios, Michael Kontos, Emmanouil Pikoulis, John Griniatsos, Apostolos Papalois, Eleftherios Spartalis, Demetrios Moris, Evangelos Felekouras, and Theodoros Liakakos. “Extended hepatectomy using the bipolar tissue sealer: an experimental model of small-for-size syndrome in pigs.Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology 21, no. 6 (November 2016): 1403–9.
Athanasiou A, Kontos M, Pikoulis E, Griniatsos J, Papalois A, Spartalis E, et al. Extended hepatectomy using the bipolar tissue sealer: an experimental model of small-for-size syndrome in pigs. Journal of BUON : official journal of the Balkan Union of Oncology. 2016 Nov;21(6):1403–9.
Athanasiou, Antonios, et al. “Extended hepatectomy using the bipolar tissue sealer: an experimental model of small-for-size syndrome in pigs.Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology, vol. 21, no. 6, Nov. 2016, pp. 1403–09.
Athanasiou A, Kontos M, Pikoulis E, Griniatsos J, Papalois A, Spartalis E, Moris D, Felekouras E, Liakakos T. Extended hepatectomy using the bipolar tissue sealer: an experimental model of small-for-size syndrome in pigs. Journal of BUON : official journal of the Balkan Union of Oncology. 2016 Nov;21(6):1403–1409.

Published In

Journal of B.U.ON. : official journal of the Balkan Union of Oncology

EISSN

2241-6293

ISSN

1107-0625

Publication Date

November 2016

Volume

21

Issue

6

Start / End Page

1403 / 1409

Related Subject Headings

  • Time Factors
  • Sus scrofa
  • Operative Time
  • Oncology & Carcinogenesis
  • Models, Animal
  • Liver Regeneration
  • Liver
  • Hepatectomy
  • Equipment Design
  • Electrocoagulation