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The Prognostic Value of CD44 Expression in Epithelial-Mesenchymal Transition: Preliminary Data from Patients with Gastric and Esophageal Cancer.

Publication ,  Journal Article
Schizas, D; Moris, D; Kanavidis, P; Michalinos, A; Sioulas, A; Pavlakis, K; Machairas, A; Liakakos, T
Published in: In vivo (Athens, Greece)
January 2016

Epithelial-mesenchymal transition is one of the mechanisms that contribute to the aggressiveness of cancer. CD44 antigen is an emerging biomarker that is currently being evaluated in the literature in the frame of epithelial-mesenchymal transition. The aim of this study was to evaluate the expression of CD44 in relation to several clinicopathological parameters in gastric and esophageal carcinomas.This historical cohort survey was performed on gastric and esophageal tumors obtained from 86 patients who underwent resection from 2003 until 2011. Immunohistochemistry was used for assessing the expression of CD44 with a semi-quantitative model.Survival rates were negatively correlated with pT at diagnosis (p<0.01), pN (p<0.01), positive lymph node ratio (p<0.01), pM (p=0.004), tumor stage (p<0.01) and grade (p<0.01), and the absence of R0 resection (p<0.01). Disease-free survival rates were affected by pN at diagnosis (p=0.02), positive lymph node ratio (p=0.03) and tumor stage (p=0.02). The correlation of tissue CD44 expression with overall and disease-free survival was not statistically significant, whereas tumor T, N, positive lymph node ratio and lymphovascular invasion were significantly associated with CD44 positivity. Moreover, tissue CD44 expression was not significantly associated with stage, histological subtype according to Lauren classification, the patient's age or gender.CD44 antigen expression might be an indicative and descriptive marker of epithelial-mesenchymal transition, mainly in gastric cancer, reflecting diverse clinicopathological events.

Duke Scholars

Published In

In vivo (Athens, Greece)

DOI

EISSN

1791-7549

ISSN

0258-851X

Publication Date

January 2016

Volume

30

Issue

6

Start / End Page

939 / 944

Related Subject Headings

  • Stomach Neoplasms
  • Prognosis
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Immunohistochemistry
  • Hyaluronan Receptors
  • Humans
  • Follow-Up Studies
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Schizas, D., Moris, D., Kanavidis, P., Michalinos, A., Sioulas, A., Pavlakis, K., … Liakakos, T. (2016). The Prognostic Value of CD44 Expression in Epithelial-Mesenchymal Transition: Preliminary Data from Patients with Gastric and Esophageal Cancer. In Vivo (Athens, Greece), 30(6), 939–944. https://doi.org/10.21873/invivo.11017
Schizas, Dimitrios, Demetrios Moris, Prodromos Kanavidis, Adamantios Michalinos, Athanasios Sioulas, Kitty Pavlakis, Anastasios Machairas, and Theodoros Liakakos. “The Prognostic Value of CD44 Expression in Epithelial-Mesenchymal Transition: Preliminary Data from Patients with Gastric and Esophageal Cancer.In Vivo (Athens, Greece) 30, no. 6 (January 2016): 939–44. https://doi.org/10.21873/invivo.11017.
Schizas D, Moris D, Kanavidis P, Michalinos A, Sioulas A, Pavlakis K, et al. The Prognostic Value of CD44 Expression in Epithelial-Mesenchymal Transition: Preliminary Data from Patients with Gastric and Esophageal Cancer. In vivo (Athens, Greece). 2016 Jan;30(6):939–44.
Schizas, Dimitrios, et al. “The Prognostic Value of CD44 Expression in Epithelial-Mesenchymal Transition: Preliminary Data from Patients with Gastric and Esophageal Cancer.In Vivo (Athens, Greece), vol. 30, no. 6, Jan. 2016, pp. 939–44. Epmc, doi:10.21873/invivo.11017.
Schizas D, Moris D, Kanavidis P, Michalinos A, Sioulas A, Pavlakis K, Machairas A, Liakakos T. The Prognostic Value of CD44 Expression in Epithelial-Mesenchymal Transition: Preliminary Data from Patients with Gastric and Esophageal Cancer. In vivo (Athens, Greece). 2016 Jan;30(6):939–944.

Published In

In vivo (Athens, Greece)

DOI

EISSN

1791-7549

ISSN

0258-851X

Publication Date

January 2016

Volume

30

Issue

6

Start / End Page

939 / 944

Related Subject Headings

  • Stomach Neoplasms
  • Prognosis
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Immunohistochemistry
  • Hyaluronan Receptors
  • Humans
  • Follow-Up Studies
  • Female