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Comparison of HRT-3 glaucoma probability score and subjective stereophotograph assessment for prediction of progression in glaucoma.

Publication ,  Journal Article
Alencar, LM; Bowd, C; Weinreb, RN; Zangwill, LM; Sample, PA; Medeiros, FA
Published in: Invest Ophthalmol Vis Sci
May 2008

PURPOSE: To assess whether baseline Glaucoma Probability Score (GPS; HRT-3; Heidelberg Engineering, Dossenheim, Germany) results are predictive of progression in patients with suspected glaucoma. The GPS is a new feature of the confocal scanning laser ophthalmoscope that generates an operator-independent, three-dimensional model of the optic nerve head and gives a score for the probability that this model is consistent with glaucomatous damage. METHODS: The study included 223 patients with suspected glaucoma during an average follow-up of 63.3 months. Included subjects had a suspect optic disc appearance and/or elevated intraocular pressure, but normal visual fields. Conversion was defined as development of either repeatable abnormal visual fields or glaucomatous deterioration in the appearance of the optic disc during the study period. The association between baseline GPS and conversion was investigated by Cox regression models. RESULTS: Fifty-four (24.2%) eyes converted. In multivariate models, both higher values of GPS global and subjective stereophotograph assessment (larger cup-disc ratio and glaucomatous grading) were predictive of conversion: adjusted hazard ratios (95% CI): 1.31 (1.15-1.50) per 0.1 higher global GPS, 1.34 (1.12-1.62) per 0.1 higher CDR, and 2.34 (1.22-4.47) for abnormal grading, respectively. No significant differences (P > 0.05 for all comparisons) were found between the c-index values (equivalent to area under ROC curve) for the multivariate models (0.732, 0.705, and 0.699, respectively). CONCLUSIONS: GPS values were predictive of conversion in our population of patients with suspected glaucoma. Further, they performed as well as subjective assessment of the optic disc. These results suggest that GPS could potentially replace stereophotograph as a tool for estimating the likelihood of conversion to glaucoma.

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Published In

Invest Ophthalmol Vis Sci

DOI

ISSN

0146-0404

Publication Date

May 2008

Volume

49

Issue

5

Start / End Page

1898 / 1906

Location

United States

Related Subject Headings

  • Visual Fields
  • Vision Disorders
  • Tomography
  • Prospective Studies
  • Probability
  • Photography
  • Optic Nerve Diseases
  • Optic Disk
  • Ophthalmoscopy
  • Ophthalmology & Optometry
 

Citation

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Alencar, L. M., Bowd, C., Weinreb, R. N., Zangwill, L. M., Sample, P. A., & Medeiros, F. A. (2008). Comparison of HRT-3 glaucoma probability score and subjective stereophotograph assessment for prediction of progression in glaucoma. Invest Ophthalmol Vis Sci, 49(5), 1898–1906. https://doi.org/10.1167/iovs.07-0111
Alencar, Luciana M., Christopher Bowd, Robert N. Weinreb, Linda M. Zangwill, Pamela A. Sample, and Felipe A. Medeiros. “Comparison of HRT-3 glaucoma probability score and subjective stereophotograph assessment for prediction of progression in glaucoma.Invest Ophthalmol Vis Sci 49, no. 5 (May 2008): 1898–1906. https://doi.org/10.1167/iovs.07-0111.
Alencar LM, Bowd C, Weinreb RN, Zangwill LM, Sample PA, Medeiros FA. Comparison of HRT-3 glaucoma probability score and subjective stereophotograph assessment for prediction of progression in glaucoma. Invest Ophthalmol Vis Sci. 2008 May;49(5):1898–906.
Alencar, Luciana M., et al. “Comparison of HRT-3 glaucoma probability score and subjective stereophotograph assessment for prediction of progression in glaucoma.Invest Ophthalmol Vis Sci, vol. 49, no. 5, May 2008, pp. 1898–906. Pubmed, doi:10.1167/iovs.07-0111.
Alencar LM, Bowd C, Weinreb RN, Zangwill LM, Sample PA, Medeiros FA. Comparison of HRT-3 glaucoma probability score and subjective stereophotograph assessment for prediction of progression in glaucoma. Invest Ophthalmol Vis Sci. 2008 May;49(5):1898–1906.

Published In

Invest Ophthalmol Vis Sci

DOI

ISSN

0146-0404

Publication Date

May 2008

Volume

49

Issue

5

Start / End Page

1898 / 1906

Location

United States

Related Subject Headings

  • Visual Fields
  • Vision Disorders
  • Tomography
  • Prospective Studies
  • Probability
  • Photography
  • Optic Nerve Diseases
  • Optic Disk
  • Ophthalmoscopy
  • Ophthalmology & Optometry