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Not Achieving Sustained Viral Eradication of Hepatitis C Virus After Treatment Leads to Worsening Patient-reported Outcomes.

Publication ,  Journal Article
Younossi, ZM; Stepanova, M; Jacobson, I; Muir, AJ; Pol, S; Zeuzem, S; Younes, Z; Herring, R; Lawitz, E; Younossi, I; Racila, A
Published in: Clin Infect Dis
February 3, 2020

BACKGROUND: The causative relationship between the clearance of infections and long-term, health-related quality-of-life (HRQL) improvements in patients with hepatitis C virus (HCV) has been generally accepted. The aim of this study was to assess long-term HRQL trends in HCV patients who did not achieve sustained virologic responses (SVRs) after treatment with direct-acting antivirals. METHODS: HCV patients who completed treatment in clinical trials and did not achieve SVRs were enrolled in a long-term registry (#NCT01457768). HRQL scores were prospectively collected using the short form-36 instrument (8 HRQL domains and 2 summary scores). RESULTS: There were 242 patients included: they had a median age of 54 years (standard deviation ± 8 years), 85% were male, and 38% had cirrhosis. Before treatment, patients' HRQL scores were similar to the general population norms (all 1-sided P > 0.05), but were followed by significant decreases by the end of treatment (-3.4 to -6.2 points; P < .05 for 5/8 HRQL domains and mental summary). By the time subjects entered the registry, all but 1 of the mean HRQL scores had returned to their pretreatment levels (P > .05). During subsequent periods in the registry, patients experienced further HRQL decrements: up to -9.2 points (P < .05 for all HRQL domains) at Week 24 and up to -8.3 points (P < .05 for 5/8 HRQL domains) at Week 48. Although these HRQL decrements were observed regardless of cirrhosis status, they were more pronounced in patients with cirrhosis (P < .05 for 3/8 HRQL domains). CONCLUSIONS: Patients who did not achieve an SVR after treatment experienced worsening HRQL scores in long-term follow-ups. Retreatment of these patients will be important not only to improve their clinical outcomes, but also their quality of life.

Duke Scholars

Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

February 3, 2020

Volume

70

Issue

4

Start / End Page

628 / 632

Location

United States

Related Subject Headings

  • Sofosbuvir
  • Quality of Life
  • Patient Reported Outcome Measures
  • Middle Aged
  • Microbiology
  • Male
  • Humans
  • Hepatitis C, Chronic
  • Hepacivirus
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Younossi, Z. M., Stepanova, M., Jacobson, I., Muir, A. J., Pol, S., Zeuzem, S., … Racila, A. (2020). Not Achieving Sustained Viral Eradication of Hepatitis C Virus After Treatment Leads to Worsening Patient-reported Outcomes. Clin Infect Dis, 70(4), 628–632. https://doi.org/10.1093/cid/ciz243
Younossi, Zobair M., Maria Stepanova, Ira Jacobson, Andrew J. Muir, Stanislas Pol, Stefan Zeuzem, Ziad Younes, et al. “Not Achieving Sustained Viral Eradication of Hepatitis C Virus After Treatment Leads to Worsening Patient-reported Outcomes.Clin Infect Dis 70, no. 4 (February 3, 2020): 628–32. https://doi.org/10.1093/cid/ciz243.
Younossi ZM, Stepanova M, Jacobson I, Muir AJ, Pol S, Zeuzem S, et al. Not Achieving Sustained Viral Eradication of Hepatitis C Virus After Treatment Leads to Worsening Patient-reported Outcomes. Clin Infect Dis. 2020 Feb 3;70(4):628–32.
Younossi, Zobair M., et al. “Not Achieving Sustained Viral Eradication of Hepatitis C Virus After Treatment Leads to Worsening Patient-reported Outcomes.Clin Infect Dis, vol. 70, no. 4, Feb. 2020, pp. 628–32. Pubmed, doi:10.1093/cid/ciz243.
Younossi ZM, Stepanova M, Jacobson I, Muir AJ, Pol S, Zeuzem S, Younes Z, Herring R, Lawitz E, Younossi I, Racila A. Not Achieving Sustained Viral Eradication of Hepatitis C Virus After Treatment Leads to Worsening Patient-reported Outcomes. Clin Infect Dis. 2020 Feb 3;70(4):628–632.
Journal cover image

Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

February 3, 2020

Volume

70

Issue

4

Start / End Page

628 / 632

Location

United States

Related Subject Headings

  • Sofosbuvir
  • Quality of Life
  • Patient Reported Outcome Measures
  • Middle Aged
  • Microbiology
  • Male
  • Humans
  • Hepatitis C, Chronic
  • Hepacivirus
  • Female