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Plasma FGF23 levels increase rapidly after acute kidney injury.

Publication ,  Journal Article
Christov, M; Waikar, SS; Pereira, RC; Havasi, A; Leaf, DE; Goltzman, D; Pajevic, PD; Wolf, M; Jüppner, H
Published in: Kidney Int
October 2013

Emerging evidence suggests that fibroblast growth factor 23 (FGF23) levels are elevated in patients with acute kidney injury (AKI). In order to determine how early this increase occurs, we used a murine folic acid-induced nephropathy model and found that plasma FGF23 levels increased significantly from baseline already after 1 h of AKI, with an 18-fold increase at 24 h. Similar elevations of FGF23 levels were found when AKI was induced in mice with osteocyte-specific parathyroid hormone receptor ablation or the global deletion of parathyroid hormone or the vitamin D receptor, indicating that the increase in FGF23 was independent of parathyroid hormone and vitamin D signaling. Furthermore, FGF23 levels increased to a similar extent in wild-type mice maintained on normal or phosphate-depleted diets prior to induction of AKI, indicating that the marked FGF23 elevation is at least partially independent of dietary phosphate. Bone production of FGF23 was significantly increased in AKI. The half-life of intravenously administered recombinant FGF23 was only modestly increased. Consistent with the mouse data, plasma FGF23 levels rose 15.9-fold by 24 h following cardiac surgery in patients who developed AKI. The levels were significantly higher than in those without postoperative AKI. Thus, circulating FGF23 levels rise rapidly during AKI in rodents and humans. In mice, this increase is independent of established modulators of FGF23 secretion.

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Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

October 2013

Volume

84

Issue

4

Start / End Page

776 / 785

Location

United States

Related Subject Headings

  • Vitamin D
  • Urology & Nephrology
  • Time Factors
  • Signal Transduction
  • Prospective Studies
  • Phosphates
  • Parathyroid Hormone
  • Mice, Inbred Strains
  • Mice, Inbred C57BL
  • Mice
 

Citation

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Christov, M., Waikar, S. S., Pereira, R. C., Havasi, A., Leaf, D. E., Goltzman, D., … Jüppner, H. (2013). Plasma FGF23 levels increase rapidly after acute kidney injury. Kidney Int, 84(4), 776–785. https://doi.org/10.1038/ki.2013.150
Christov, Marta, Sushrut S. Waikar, Renata C. Pereira, Andrea Havasi, David E. Leaf, David Goltzman, Paola D. Pajevic, Myles Wolf, and Harald Jüppner. “Plasma FGF23 levels increase rapidly after acute kidney injury.Kidney Int 84, no. 4 (October 2013): 776–85. https://doi.org/10.1038/ki.2013.150.
Christov M, Waikar SS, Pereira RC, Havasi A, Leaf DE, Goltzman D, et al. Plasma FGF23 levels increase rapidly after acute kidney injury. Kidney Int. 2013 Oct;84(4):776–85.
Christov, Marta, et al. “Plasma FGF23 levels increase rapidly after acute kidney injury.Kidney Int, vol. 84, no. 4, Oct. 2013, pp. 776–85. Pubmed, doi:10.1038/ki.2013.150.
Christov M, Waikar SS, Pereira RC, Havasi A, Leaf DE, Goltzman D, Pajevic PD, Wolf M, Jüppner H. Plasma FGF23 levels increase rapidly after acute kidney injury. Kidney Int. 2013 Oct;84(4):776–785.
Journal cover image

Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

October 2013

Volume

84

Issue

4

Start / End Page

776 / 785

Location

United States

Related Subject Headings

  • Vitamin D
  • Urology & Nephrology
  • Time Factors
  • Signal Transduction
  • Prospective Studies
  • Phosphates
  • Parathyroid Hormone
  • Mice, Inbred Strains
  • Mice, Inbred C57BL
  • Mice