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Vitamin D levels and early mortality among incident hemodialysis patients.

Publication ,  Journal Article
Wolf, M; Shah, A; Gutierrez, O; Ankers, E; Monroy, M; Tamez, H; Steele, D; Chang, Y; Camargo, CA; Tonelli, M; Thadhani, R
Published in: Kidney Int
October 2007

Vitamin D deficiency is associated with cardiovascular disease, the most common cause of mortality in hemodialysis patients. To investigate the relation between blood levels of 25-hydroxyvitamin D (25D) and 1,25-dihydroxyvitamin D (1,25D) with hemodialysis outcomes, we measured baseline vitamin D levels in a cross-sectional analysis of 825 consecutive patients from within a prospective cohort of incident US hemodialysis patients. Of these patients, 78% were considered vitamin D deficient with 18% considered severely deficient. Calcium, phosphorus, and parathyroid hormone levels correlated poorly with 25D and 1,25D concentrations. To test the association between baseline vitamin D levels and 90-day mortality, we selected the next 175 consecutive participants who died within 90 days and compared them to the 750 patients who survived in a nested case-control analysis. While low vitamin D levels were associated with increased mortality, significant interaction was noted between vitamin D levels, subsequent active vitamin D therapy, and survival. Compared to patients with the highest 25D or 1,25D levels who received therapy, untreated deficient patients were at significantly increased risk for early mortality. Our study shows that among incident hemodialysis patients, vitamin D deficiency is common, correlates poorly with other components of mineral metabolism and is associated with increased early mortality.

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Published In

Kidney Int

DOI

ISSN

0085-2538

Publication Date

October 2007

Volume

72

Issue

8

Start / End Page

1004 / 1013

Location

United States

Related Subject Headings

  • Vitamin D Deficiency
  • Vitamin D
  • Urology & Nephrology
  • Survival Analysis
  • Risk Factors
  • Renal Dialysis
  • Prospective Studies
  • Phosphorus
  • Parathyroid Hormone
  • Multivariate Analysis
 

Citation

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Wolf, M., Shah, A., Gutierrez, O., Ankers, E., Monroy, M., Tamez, H., … Thadhani, R. (2007). Vitamin D levels and early mortality among incident hemodialysis patients. Kidney Int, 72(8), 1004–1013. https://doi.org/10.1038/sj.ki.5002451
Wolf, M., A. Shah, O. Gutierrez, E. Ankers, M. Monroy, H. Tamez, D. Steele, et al. “Vitamin D levels and early mortality among incident hemodialysis patients.Kidney Int 72, no. 8 (October 2007): 1004–13. https://doi.org/10.1038/sj.ki.5002451.
Wolf M, Shah A, Gutierrez O, Ankers E, Monroy M, Tamez H, et al. Vitamin D levels and early mortality among incident hemodialysis patients. Kidney Int. 2007 Oct;72(8):1004–13.
Wolf, M., et al. “Vitamin D levels and early mortality among incident hemodialysis patients.Kidney Int, vol. 72, no. 8, Oct. 2007, pp. 1004–13. Pubmed, doi:10.1038/sj.ki.5002451.
Wolf M, Shah A, Gutierrez O, Ankers E, Monroy M, Tamez H, Steele D, Chang Y, Camargo CA, Tonelli M, Thadhani R. Vitamin D levels and early mortality among incident hemodialysis patients. Kidney Int. 2007 Oct;72(8):1004–1013.
Journal cover image

Published In

Kidney Int

DOI

ISSN

0085-2538

Publication Date

October 2007

Volume

72

Issue

8

Start / End Page

1004 / 1013

Location

United States

Related Subject Headings

  • Vitamin D Deficiency
  • Vitamin D
  • Urology & Nephrology
  • Survival Analysis
  • Risk Factors
  • Renal Dialysis
  • Prospective Studies
  • Phosphorus
  • Parathyroid Hormone
  • Multivariate Analysis