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Visual Acuity Outcomes after Anti-Vascular Endothelial Growth Factor Treatment for Neovascular Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report Number 19.

Publication ,  Journal Article
Keenan, TD; Vitale, S; Agrón, E; Domalpally, A; Antoszyk, AN; Elman, MJ; Clemons, TE; Chew, EY; Age-Related Eye Disease Study 2 Research Group,
Published in: Ophthalmol Retina
January 2020

PURPOSE: To analyze best-corrected visual acuity (BCVA) outcomes after anti-vascular endothelial growth factor (VEGF) treatment for neovascular age-related macular degeneration (AMD). DESIGN: Prospective cohort study of participants enrolled in a clinical trial of oral supplements and receiving anti-VEGF therapy in routine clinical practice. PARTICIPANTS: Age-Related Eye Disease Study 2 (AREDS2) participants (50-85 years of age) whose eyes met AREDS2 inclusion criteria at baseline (no late AMD, BCVA ≥20/100, no previous anti-VEGF injections) but received at least 1 anti-VEGF injection for incident neovascular AMD during follow-up. METHODS: Participants underwent refracted BCVA testing, ophthalmoscopic examination, and stereoscopic color fundus photography at baseline and annual study visits over 5 years. Self-reports of anti-VEGF injections (numbers, dates, and names of drug) were collected at baseline and annual study visits and during telephone calls every 6 months. MAIN OUTCOME MEASURES: Primary outcome measures were mean refracted BCVA and proportions of eyes with BCVA of 20/40 or better and 20/200 or worse. An exploratory outcome measure was the mean number of self-reported anti-VEGF injections. RESULTS: One thousand one hundred five eyes of 986 AREDS2 participants met the inclusion criteria; of these, 977 participants (99.1%) underwent at least 1 posttreatment visit. At the first and subsequent annual examinations after the first injection, mean refracted BCVAs were 68.0 letters (Snellen equivalent, 20/40), 66.1 letters, 64.7 letters, 63.2 letters, and 61.5 letters (Snellen equivalent, 20/60). Proportions of eyes with BCVA of 20/40 or better were 59.3%, 55.1%, 53.5%, 50.6%, and 49.7%, and those with BCVA of 20/200 or worse were 5.5%, 8.6%, 9.4%, 12.4%, and 14.4%. Mean annual numbers of self-reported anti-VEGF injections per eye were 2.9, 3.9, 3.3, 3.1, and 3.0. CONCLUSIONS: Refracted BCVA data were obtained in a clinical trial environment but were related to anti-VEGF treatment administered in normal clinical practice. Visual outcomes declined slowly with increased follow-up time: mean BCVA decreased by approximately 1.5 to 2 letters per year. At 5 years, half of eyes achieved BCVA of 20/40 or better, but approximately one sixth showed BCVA of 20/200 or worse. These data may be useful in assessing the long-term effects of anti-VEGF therapy.

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Published In

Ophthalmol Retina

DOI

EISSN

2468-6530

Publication Date

January 2020

Volume

4

Issue

1

Start / End Page

3 / 12

Location

United States

Related Subject Headings

  • Zeaxanthins
  • Wet Macular Degeneration
  • Visual Acuity
  • Vascular Endothelial Growth Factor A
  • Treatment Outcome
  • Surveys and Questionnaires
  • Prospective Studies
  • Middle Aged
  • Male
  • Lutein
 

Citation

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Keenan, T. D., Vitale, S., Agrón, E., Domalpally, A., Antoszyk, A. N., Elman, M. J., … Age-Related Eye Disease Study 2 Research Group, . (2020). Visual Acuity Outcomes after Anti-Vascular Endothelial Growth Factor Treatment for Neovascular Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report Number 19. Ophthalmol Retina, 4(1), 3–12. https://doi.org/10.1016/j.oret.2019.06.001
Keenan, Tiarnan D., Susan Vitale, Elvira Agrón, Amitha Domalpally, Andrew N. Antoszyk, Michael J. Elman, Traci E. Clemons, Emily Y. Chew, and Emily Y. Age-Related Eye Disease Study 2 Research Group. “Visual Acuity Outcomes after Anti-Vascular Endothelial Growth Factor Treatment for Neovascular Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report Number 19.Ophthalmol Retina 4, no. 1 (January 2020): 3–12. https://doi.org/10.1016/j.oret.2019.06.001.
Keenan, Tiarnan D., et al. “Visual Acuity Outcomes after Anti-Vascular Endothelial Growth Factor Treatment for Neovascular Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report Number 19.Ophthalmol Retina, vol. 4, no. 1, Jan. 2020, pp. 3–12. Pubmed, doi:10.1016/j.oret.2019.06.001.
Keenan TD, Vitale S, Agrón E, Domalpally A, Antoszyk AN, Elman MJ, Clemons TE, Chew EY, Age-Related Eye Disease Study 2 Research Group. Visual Acuity Outcomes after Anti-Vascular Endothelial Growth Factor Treatment for Neovascular Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report Number 19. Ophthalmol Retina. 2020 Jan;4(1):3–12.
Journal cover image

Published In

Ophthalmol Retina

DOI

EISSN

2468-6530

Publication Date

January 2020

Volume

4

Issue

1

Start / End Page

3 / 12

Location

United States

Related Subject Headings

  • Zeaxanthins
  • Wet Macular Degeneration
  • Visual Acuity
  • Vascular Endothelial Growth Factor A
  • Treatment Outcome
  • Surveys and Questionnaires
  • Prospective Studies
  • Middle Aged
  • Male
  • Lutein