Skip to main content
Journal cover image

Metabolic regulation of epigenetic remodeling in immune cells.

Publication ,  Journal Article
Britt, EC; John, SV; Locasale, JW; Fan, J
Published in: Curr Opin Biotechnol
June 2020

Immune cells are capable of sensing various signals in the microenvironment and turning on specific immune functions in response. The appropriate transition of immune cells into diverse functional states, which is crucial for immunity, involves complex and well-regulated changes in transcriptional program. Accumulating evidence shows that epigenetic remodeling plays a central role in mediating the transcriptional program for immune cell activation and immunological memory. Concurrently, immune cells undergo significant metabolic reprogramming during immune response. Here we review recent studies that demonstrate shifts in metabolic state can orchestrate immune cell functions through its impact on epigenetic remodeling, and the microenvironment can exert its influence on immune cells through the metabolic regulation of epigenetics. We also discuss the systems biology approaches that enabled these discoveries.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Curr Opin Biotechnol

DOI

EISSN

1879-0429

Publication Date

June 2020

Volume

63

Start / End Page

111 / 117

Location

England

Related Subject Headings

  • Immunity
  • Epigenomics
  • Epigenesis, Genetic
  • Biotechnology
  • 3206 Medical biotechnology
  • 3106 Industrial biotechnology
  • 3001 Agricultural biotechnology
  • 10 Technology
  • 09 Engineering
  • 06 Biological Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Britt, E. C., John, S. V., Locasale, J. W., & Fan, J. (2020). Metabolic regulation of epigenetic remodeling in immune cells. Curr Opin Biotechnol, 63, 111–117. https://doi.org/10.1016/j.copbio.2019.12.008
Britt, Emily C., Steven V. John, Jason W. Locasale, and Jing Fan. “Metabolic regulation of epigenetic remodeling in immune cells.Curr Opin Biotechnol 63 (June 2020): 111–17. https://doi.org/10.1016/j.copbio.2019.12.008.
Britt EC, John SV, Locasale JW, Fan J. Metabolic regulation of epigenetic remodeling in immune cells. Curr Opin Biotechnol. 2020 Jun;63:111–7.
Britt, Emily C., et al. “Metabolic regulation of epigenetic remodeling in immune cells.Curr Opin Biotechnol, vol. 63, June 2020, pp. 111–17. Pubmed, doi:10.1016/j.copbio.2019.12.008.
Britt EC, John SV, Locasale JW, Fan J. Metabolic regulation of epigenetic remodeling in immune cells. Curr Opin Biotechnol. 2020 Jun;63:111–117.
Journal cover image

Published In

Curr Opin Biotechnol

DOI

EISSN

1879-0429

Publication Date

June 2020

Volume

63

Start / End Page

111 / 117

Location

England

Related Subject Headings

  • Immunity
  • Epigenomics
  • Epigenesis, Genetic
  • Biotechnology
  • 3206 Medical biotechnology
  • 3106 Industrial biotechnology
  • 3001 Agricultural biotechnology
  • 10 Technology
  • 09 Engineering
  • 06 Biological Sciences