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Immunometabolism: From basic mechanisms to translation.

Publication ,  Journal Article
Makowski, L; Chaib, M; Rathmell, JC
Published in: Immunological reviews
May 2020

Immunometabolism has emerged as a major mechanism central to adaptive and innate immune regulation. From early observations that inflammatory cytokines were induced in obese adipose tissue and that these cytokines contributed to metabolic disease, it was clear that metabolism and the immunological state are inextricably linked. With a second research wave arising from studies in cancer metabolism to also study the intrinsic metabolic pathways of immune cells themselves and how those pathways influence cell fate and function, immunometabolism is a rapidly maturing area of research. Several key themes and goals drive the field. There is abundant evidence that metabolic pathways are closely tied to cell signaling and differentiation which leads different subsets of immune cells to adopt unique metabolic programs specific to their state and environment. In this way, metabolic signaling drives cell fate. It is also apparent that microenvironment greatly influences cell metabolism. Immune cells adopt programs specific for the tissues where they infiltrate and reside. Ultimately, a central goal of the field is to apply immunometabolism findings to the discovery of novel therapeutic strategies in a wide range of diseases, including cancer, autoimmunity, and metabolic syndrome. This review summarizes these facets of immunometabolism and highlights opportunities for clinical translation.

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Published In

Immunological reviews

DOI

EISSN

1600-065X

ISSN

0105-2896

Publication Date

May 2020

Volume

295

Issue

1

Start / End Page

5 / 14

Related Subject Headings

  • Translational Research, Biomedical
  • Organ Specificity
  • Immunomodulation
  • Immunology
  • Immunity, Innate
  • Immunity
  • Humans
  • Energy Metabolism
  • Disease Susceptibility
  • Animals
 

Citation

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Makowski, L., Chaib, M., & Rathmell, J. C. (2020). Immunometabolism: From basic mechanisms to translation. Immunological Reviews, 295(1), 5–14. https://doi.org/10.1111/imr.12858
Makowski, Liza, Mehdi Chaib, and Jeffrey C. Rathmell. “Immunometabolism: From basic mechanisms to translation.Immunological Reviews 295, no. 1 (May 2020): 5–14. https://doi.org/10.1111/imr.12858.
Makowski L, Chaib M, Rathmell JC. Immunometabolism: From basic mechanisms to translation. Immunological reviews. 2020 May;295(1):5–14.
Makowski, Liza, et al. “Immunometabolism: From basic mechanisms to translation.Immunological Reviews, vol. 295, no. 1, May 2020, pp. 5–14. Epmc, doi:10.1111/imr.12858.
Makowski L, Chaib M, Rathmell JC. Immunometabolism: From basic mechanisms to translation. Immunological reviews. 2020 May;295(1):5–14.
Journal cover image

Published In

Immunological reviews

DOI

EISSN

1600-065X

ISSN

0105-2896

Publication Date

May 2020

Volume

295

Issue

1

Start / End Page

5 / 14

Related Subject Headings

  • Translational Research, Biomedical
  • Organ Specificity
  • Immunomodulation
  • Immunology
  • Immunity, Innate
  • Immunity
  • Humans
  • Energy Metabolism
  • Disease Susceptibility
  • Animals