
Transgelin-2: Biochemical and Clinical Implications in Cancer and Asthma.
Transgelin-2 has been regarded as an actin-binding protein that induces actin gelation and regulates actin cytoskeleton. However, transgelin-2 has recently been shown to relax the myosin cytoskeleton of the airway smooth muscle cells by acting as a receptor for extracellular metallothionein-2. From a clinical perspective, these results support transgelin-2 as a promising therapeutic target for diseases such as cancer and asthma. The inhibition of transgelin-2 prevents actin gelation and thereby cancer cell proliferation, invasion, and metastasis. Conversely, the activation of transgelin-2 with specific agonists relaxes airway smooth muscles and reduces pulmonary resistance in asthma. Here, we review new studies on the biochemical properties of transgelin-2 and discuss their clinical implications for the treatment of immune, oncogenic, and respiratory disorders.
Duke Scholars
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Related Subject Headings
- Neoplasms
- Muscle Proteins
- Microfilament Proteins
- Humans
- Developmental Biology
- Cell Proliferation
- Asthma
- Animals
- Actins
- 3404 Medicinal and biomolecular chemistry
Citation

Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Neoplasms
- Muscle Proteins
- Microfilament Proteins
- Humans
- Developmental Biology
- Cell Proliferation
- Asthma
- Animals
- Actins
- 3404 Medicinal and biomolecular chemistry