Skip to main content
release_alert
Welcome to the new Scholars 3.0! Read about new features and let us know what you think.
cancel
Journal cover image

Transgelin-2: Biochemical and Clinical Implications in Cancer and Asthma.

Publication ,  Journal Article
Yin, L-M; Ulloa, L; Yang, Y-Q
Published in: Trends Biochem Sci
October 2019

Transgelin-2 has been regarded as an actin-binding protein that induces actin gelation and regulates actin cytoskeleton. However, transgelin-2 has recently been shown to relax the myosin cytoskeleton of the airway smooth muscle cells by acting as a receptor for extracellular metallothionein-2. From a clinical perspective, these results support transgelin-2 as a promising therapeutic target for diseases such as cancer and asthma. The inhibition of transgelin-2 prevents actin gelation and thereby cancer cell proliferation, invasion, and metastasis. Conversely, the activation of transgelin-2 with specific agonists relaxes airway smooth muscles and reduces pulmonary resistance in asthma. Here, we review new studies on the biochemical properties of transgelin-2 and discuss their clinical implications for the treatment of immune, oncogenic, and respiratory disorders.

Duke Scholars

Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

October 2019

Volume

44

Issue

10

Start / End Page

885 / 896

Location

England

Related Subject Headings

  • Neoplasms
  • Muscle Proteins
  • Microfilament Proteins
  • Humans
  • Developmental Biology
  • Cell Proliferation
  • Asthma
  • Animals
  • Actins
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yin, L.-M., Ulloa, L., & Yang, Y.-Q. (2019). Transgelin-2: Biochemical and Clinical Implications in Cancer and Asthma. Trends Biochem Sci, 44(10), 885–896. https://doi.org/10.1016/j.tibs.2019.05.004
Yin, Lei-Miao, Luis Ulloa, and Yong-Qing Yang. “Transgelin-2: Biochemical and Clinical Implications in Cancer and Asthma.Trends Biochem Sci 44, no. 10 (October 2019): 885–96. https://doi.org/10.1016/j.tibs.2019.05.004.
Yin L-M, Ulloa L, Yang Y-Q. Transgelin-2: Biochemical and Clinical Implications in Cancer and Asthma. Trends Biochem Sci. 2019 Oct;44(10):885–96.
Yin, Lei-Miao, et al. “Transgelin-2: Biochemical and Clinical Implications in Cancer and Asthma.Trends Biochem Sci, vol. 44, no. 10, Oct. 2019, pp. 885–96. Pubmed, doi:10.1016/j.tibs.2019.05.004.
Yin L-M, Ulloa L, Yang Y-Q. Transgelin-2: Biochemical and Clinical Implications in Cancer and Asthma. Trends Biochem Sci. 2019 Oct;44(10):885–896.
Journal cover image

Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

October 2019

Volume

44

Issue

10

Start / End Page

885 / 896

Location

England

Related Subject Headings

  • Neoplasms
  • Muscle Proteins
  • Microfilament Proteins
  • Humans
  • Developmental Biology
  • Cell Proliferation
  • Asthma
  • Animals
  • Actins
  • 11 Medical and Health Sciences