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Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress.

Publication ,  Journal Article
Bernardes, N; da Silva Dias, D; Stoyell-Conti, FF; de Oliveira Brito-Monzani, J; Malfitano, C; Caldini, EG; Ulloa, L; Llesuy, SF; Irigoyen, M-C ...
Published in: Scientific reports
June 2018

This study analyzes whether autonomic dysfunction precedes cardiometabolic alterations in spontaneously hypertensive rats (SHR) with fructose overload. Animals were randomly distributed into three groups: control, hypertensive and hypertensive with fructose overload. Fructose overload (100 g/L) was initiated at 30 days old, and the animals (n = 6/group/time) were evaluated after 7, 15, 30 and 60 days of fructose consumption. Fructose consumption reduced baroreflex sensitivity by day 7, and still induced a progressive reduction in baroreflex sensitivity over the time. Fructose consumption also increased TNFα and IL-6 levels in the adipose tissue and IL-1β levels in the spleen at days 15 and 30. Fructose consumption also reduced plasmatic nitrites (day 15 and 30) and superoxide dismutase activity (day 15 and 60), but increased hydrogen peroxide (day 30 and 60), lipid peroxidation and protein oxidation (day 60). Fructose consumption increased arterial pressure at day 30 (8%) and 60 (11%). Fructose consumption also induced a late insulin resistance at day 60, but did not affect glucose levels. In conclusion, the results show that baroreflex sensitivity impairment precedes inflammatory and oxidative stress disorders, probably by inducing hemodynamic and metabolic dysfunctions observed in metabolic syndrome.

Published In

Scientific reports

DOI

EISSN

2045-2322

ISSN

2045-2322

Publication Date

June 2018

Volume

8

Issue

1

Start / End Page

8578

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Rats, Wistar
  • Rats, Inbred SHR
  • Oxidative Stress
  • Myocardium
  • Metabolic Syndrome
  • Male
  • Interleukin-6
  • Insulin Resistance
  • Inflammation
 

Citation

APA
Chicago
ICMJE
MLA
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Bernardes, N., da Silva Dias, D., Stoyell-Conti, F. F., de Oliveira Brito-Monzani, J., Malfitano, C., Caldini, E. G., … De Angelis, K. (2018). Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress. Scientific Reports, 8(1), 8578. https://doi.org/10.1038/s41598-018-26816-4
Bernardes, Nathalia, Danielle da Silva Dias, Filipe Fernandes Stoyell-Conti, Janaina de Oliveira Brito-Monzani, Christiane Malfitano, Elia Garcia Caldini, Luis Ulloa, Susana Francisca Llesuy, Maria-Cláudia Irigoyen, and Kátia De Angelis. “Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress.Scientific Reports 8, no. 1 (June 2018): 8578. https://doi.org/10.1038/s41598-018-26816-4.
Bernardes N, da Silva Dias D, Stoyell-Conti FF, de Oliveira Brito-Monzani J, Malfitano C, Caldini EG, et al. Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress. Scientific reports. 2018 Jun;8(1):8578.
Bernardes, Nathalia, et al. “Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress.Scientific Reports, vol. 8, no. 1, June 2018, p. 8578. Epmc, doi:10.1038/s41598-018-26816-4.
Bernardes N, da Silva Dias D, Stoyell-Conti FF, de Oliveira Brito-Monzani J, Malfitano C, Caldini EG, Ulloa L, Llesuy SF, Irigoyen M-C, De Angelis K. Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress. Scientific reports. 2018 Jun;8(1):8578.

Published In

Scientific reports

DOI

EISSN

2045-2322

ISSN

2045-2322

Publication Date

June 2018

Volume

8

Issue

1

Start / End Page

8578

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Rats, Wistar
  • Rats, Inbred SHR
  • Oxidative Stress
  • Myocardium
  • Metabolic Syndrome
  • Male
  • Interleukin-6
  • Insulin Resistance
  • Inflammation