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Role of phosphorylated MAPlB in neuritogenesis.

Publication ,  Journal Article
Avila, J; Ulloa, L; Diez-Guerra, J; Diaz-Nido, J
Published in: Cell biology international
May 1994

The distribution of microtubule-associated protein lB (MAPlB) phosphorylated by either proline-directed protein kinase (PDPK) or casein kinase II (CK II) in neuroblastoma cells and hippocampal neurons has been studied by immunofluorescence using specific antibodies to distinct phosphorylation-sensitive epitopes. A proximo-distal gradient of increasing PDPK-catalyzed phosphorylation of MAPlB is superimposed on a proximo distal gradient of decreasing CK II-catalyzed MAPlB phosphorylation within growing axon-like neurites. Additionally, CK II-phosphorylated MAPlB is present in cell bodies and dendrites where no PDPK-phosphorylated MAPlB is observed. These results suggest distinct roles for both types of modifications of MAPlB in developing neurons.

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Published In

Cell biology international

DOI

EISSN

1095-8355

ISSN

1065-6995

Publication Date

May 1994

Volume

18

Issue

5

Start / End Page

309 / 314

Related Subject Headings

  • Tumor Cells, Cultured
  • Rats
  • Protein Serine-Threonine Kinases
  • Proline-Directed Protein Kinases
  • Phosphorylation
  • Neurons
  • Neuroblastoma
  • Neurites
  • Microtubule-Associated Proteins
  • Mice
 

Citation

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Avila, J., Ulloa, L., Diez-Guerra, J., & Diaz-Nido, J. (1994). Role of phosphorylated MAPlB in neuritogenesis. Cell Biology International, 18(5), 309–314. https://doi.org/10.1006/cbir.1994.1079
Avila, J., L. Ulloa, J. Diez-Guerra, and J. Diaz-Nido. “Role of phosphorylated MAPlB in neuritogenesis.Cell Biology International 18, no. 5 (May 1994): 309–14. https://doi.org/10.1006/cbir.1994.1079.
Avila J, Ulloa L, Diez-Guerra J, Diaz-Nido J. Role of phosphorylated MAPlB in neuritogenesis. Cell biology international. 1994 May;18(5):309–14.
Avila, J., et al. “Role of phosphorylated MAPlB in neuritogenesis.Cell Biology International, vol. 18, no. 5, May 1994, pp. 309–14. Epmc, doi:10.1006/cbir.1994.1079.
Avila J, Ulloa L, Diez-Guerra J, Diaz-Nido J. Role of phosphorylated MAPlB in neuritogenesis. Cell biology international. 1994 May;18(5):309–314.
Journal cover image

Published In

Cell biology international

DOI

EISSN

1095-8355

ISSN

1065-6995

Publication Date

May 1994

Volume

18

Issue

5

Start / End Page

309 / 314

Related Subject Headings

  • Tumor Cells, Cultured
  • Rats
  • Protein Serine-Threonine Kinases
  • Proline-Directed Protein Kinases
  • Phosphorylation
  • Neurons
  • Neuroblastoma
  • Neurites
  • Microtubule-Associated Proteins
  • Mice