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Brief Report: Can a Composite Heart Rate Variability Biomarker Shed New Insights About Autism Spectrum Disorder in School-Aged Children?

Publication ,  Journal Article
Frasch, MG; Shen, C; Wu, H-T; Mueller, A; Neuhaus, E; Bernier, RA; Kamara, D; Beauchaine, TP
Published in: Journal of autism and developmental disorders
January 2021

Several studies show altered heart rate variability (HRV) in autism spectrum disorder (ASD), but findings are neither universal nor specific to ASD. We apply a set of linear and nonlinear HRV measures-including phase rectified signal averaging-to segments of resting ECG data collected from school-age children with ASD, age-matched typically developing controls, and children with other psychiatric conditions characterized by altered HRV (conduct disorder, depression). We use machine learning to identify time, frequency, and geometric signal-analytical domains that are specific to ASD (receiver operating curve area = 0.89). This is the first study to differentiate children with ASD from other disorders characterized by altered HRV. Despite a small cohort and lack of external validation, results warrant larger prospective studies.

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Published In

Journal of autism and developmental disorders

DOI

EISSN

1573-3432

ISSN

0162-3257

Publication Date

January 2021

Volume

51

Issue

1

Start / End Page

346 / 356

Related Subject Headings

  • Students
  • Schools
  • Rest
  • Prospective Studies
  • Problem Solving
  • Male
  • Machine Learning
  • Humans
  • Heart Rate
  • Female
 

Citation

APA
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MLA
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Frasch, M. G., Shen, C., Wu, H.-T., Mueller, A., Neuhaus, E., Bernier, R. A., … Beauchaine, T. P. (2021). Brief Report: Can a Composite Heart Rate Variability Biomarker Shed New Insights About Autism Spectrum Disorder in School-Aged Children? Journal of Autism and Developmental Disorders, 51(1), 346–356. https://doi.org/10.1007/s10803-020-04467-7
Frasch, Martin G., Chao Shen, Hau-Tieng Wu, Alexander Mueller, Emily Neuhaus, Raphael A. Bernier, Dana Kamara, and Theodore P. Beauchaine. “Brief Report: Can a Composite Heart Rate Variability Biomarker Shed New Insights About Autism Spectrum Disorder in School-Aged Children?Journal of Autism and Developmental Disorders 51, no. 1 (January 2021): 346–56. https://doi.org/10.1007/s10803-020-04467-7.
Frasch MG, Shen C, Wu H-T, Mueller A, Neuhaus E, Bernier RA, et al. Brief Report: Can a Composite Heart Rate Variability Biomarker Shed New Insights About Autism Spectrum Disorder in School-Aged Children? Journal of autism and developmental disorders. 2021 Jan;51(1):346–56.
Frasch, Martin G., et al. “Brief Report: Can a Composite Heart Rate Variability Biomarker Shed New Insights About Autism Spectrum Disorder in School-Aged Children?Journal of Autism and Developmental Disorders, vol. 51, no. 1, Jan. 2021, pp. 346–56. Epmc, doi:10.1007/s10803-020-04467-7.
Frasch MG, Shen C, Wu H-T, Mueller A, Neuhaus E, Bernier RA, Kamara D, Beauchaine TP. Brief Report: Can a Composite Heart Rate Variability Biomarker Shed New Insights About Autism Spectrum Disorder in School-Aged Children? Journal of autism and developmental disorders. 2021 Jan;51(1):346–356.
Journal cover image

Published In

Journal of autism and developmental disorders

DOI

EISSN

1573-3432

ISSN

0162-3257

Publication Date

January 2021

Volume

51

Issue

1

Start / End Page

346 / 356

Related Subject Headings

  • Students
  • Schools
  • Rest
  • Prospective Studies
  • Problem Solving
  • Male
  • Machine Learning
  • Humans
  • Heart Rate
  • Female