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N95 Reprocessing by Low Temperature Sterilization with 59% Vaporized Hydrogen Peroxide during the 2020 COVID-19 Pandemic

Publication ,  Journal Article
Jatta, M; Kiefer, C; Patolia, H; Pan, J; Harb, C; Marr, LC; Baffoe-Bonnie, A
Published in: American Journal of Infection Control
June 26, 2020

BACKGROUND: Response to the COVID-19 pandemic by hospital systems has been strained by severe shortages in personal protective equipment (PPE), particularly N95 respirators. Recently, the Centers for Disease Control and Prevention endorsed decontamination strategies to prolong the lifespan of single use respirators. Battelle and Duke University have validated hospital protocols to decontaminate respirators using vaporized hydrogen peroxide (VHP) at 30%-35% concentrations. To prolong our supply of respirators, we evaluated and implemented VHP decontamination at 59% hydrogen peroxide concentration while detailing the effects of this process on the filtration efficiency and quantitative fit of single-use respirators. This study may help other health systems develop local solutions to their N95 mask shortage during this COVID-19 pandemic. METHODS: N95 respirators (3M 8211 FF and 9210 FF) that were treated with 5 and 10 cycles of VHP by the V-PRO® maX Low Temperature Sterilization System were evaluated quantitatively for filtration efficiency as well as with quantitative fit testing per Occupational Safety and Health Administration standards. A decontamination protocol was concurrently implemented at our institution. This process involved depositing used masks, reprocessing, and re-distributing treated masks efficiently back to frontline providers. Furthermore, we implemented patient safety officers (PSO) on COVID-19/person under investigation (PUI) units to ensure optimized donning/doffing of respirators through frontline provider education. RESULTS: There were no statistically significant changes in mean filtration efficiency between the control and VHP-treated respirators. Furthermore, both treated and untreated respirators demonstrated fit factors above the minimum pass requirement. CONCLUSION: We have successfully demonstrated that N95 respirator decontamination with VHP at 59% hydrogen peroxide can be safely utilized to decontaminate single-use N95 respirators without significant effects on filtration efficiency or quantitative fit testing. With the COVID-19 pandemic and N95 respirator shortage, health systems without access to commercial decontamination processes should investigate the viability of such a process in their facilities.

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Published In

American Journal of Infection Control

DOI

ISSN

1527-3296

Publication Date

June 26, 2020

Start / End Page

S0196-6553(20)30576-9

Publisher

Published by Elsevier Inc. on behalf of Association for Professionals in Infection Control and Epidemiology, Inc.

Related Subject Headings

  • Volatilization
  • Sterilization
  • SARS-CoV-2
  • Personal Protective Equipment
  • N95 Respirators
  • Materials Testing
  • Hydrogen Peroxide
  • Humans
  • Equipment Reuse
  • Epidemiology
 

Citation

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Jatta, M., Kiefer, C., Patolia, H., Pan, J., Harb, C., Marr, L. C., & Baffoe-Bonnie, A. (2020). N95 Reprocessing by Low Temperature Sterilization with 59% Vaporized Hydrogen Peroxide during the 2020 COVID-19 Pandemic. American Journal of Infection Control, S0196-6553(20)30576-9. https://doi.org/10.1016/j.ajic.2020.06.194
Jatta, M., C. Kiefer, H. Patolia, J. Pan, C. Harb, L. C. Marr, and A. Baffoe-Bonnie. “N95 Reprocessing by Low Temperature Sterilization with 59% Vaporized Hydrogen Peroxide during the 2020 COVID-19 Pandemic.” American Journal of Infection Control, June 26, 2020, S0196-6553(20)30576-9. https://doi.org/10.1016/j.ajic.2020.06.194.
Jatta M, Kiefer C, Patolia H, Pan J, Harb C, Marr LC, et al. N95 Reprocessing by Low Temperature Sterilization with 59% Vaporized Hydrogen Peroxide during the 2020 COVID-19 Pandemic. American Journal of Infection Control. 2020 Jun 26;S0196-6553(20)30576-9.
Jatta, M., et al. “N95 Reprocessing by Low Temperature Sterilization with 59% Vaporized Hydrogen Peroxide during the 2020 COVID-19 Pandemic.” American Journal of Infection Control, Published by Elsevier Inc. on behalf of Association for Professionals in Infection Control and Epidemiology, Inc., June 2020, pp. S0196-6553(20)30576-9. Manual, doi:10.1016/j.ajic.2020.06.194.
Jatta M, Kiefer C, Patolia H, Pan J, Harb C, Marr LC, Baffoe-Bonnie A. N95 Reprocessing by Low Temperature Sterilization with 59% Vaporized Hydrogen Peroxide during the 2020 COVID-19 Pandemic. American Journal of Infection Control. Published by Elsevier Inc. on behalf of Association for Professionals in Infection Control and Epidemiology, Inc.; 2020 Jun 26;S0196-6553(20)30576–9.
Journal cover image

Published In

American Journal of Infection Control

DOI

ISSN

1527-3296

Publication Date

June 26, 2020

Start / End Page

S0196-6553(20)30576-9

Publisher

Published by Elsevier Inc. on behalf of Association for Professionals in Infection Control and Epidemiology, Inc.

Related Subject Headings

  • Volatilization
  • Sterilization
  • SARS-CoV-2
  • Personal Protective Equipment
  • N95 Respirators
  • Materials Testing
  • Hydrogen Peroxide
  • Humans
  • Equipment Reuse
  • Epidemiology