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Enrichment of malondialdehyde-acetaldehyde antibody in the rheumatoid arthritis joint.

Publication ,  Journal Article
Mikuls, TR; Duryee, MJ; Rahman, R; Anderson, DR; Sayles, HR; Hollins, A; Michaud, K; Wolfe, F; Thiele, GE; Sokolove, J; Robinson, WH; Su, K ...
Published in: Rheumatology (Oxford, England)
October 2017

To characterize the expression of malondialdehdye-acetaldehyde (MAA) adducts and anti-MAA antibody in articular tissues and serum of patients with RA.Paired sera and SF were examined from 29 RA and 13 OA patients. Anti-MAA antibody, RF, ACPA and total immunoglobulin were quantified. SF-serum measures were compared within and between disease groups. The presence and co-localization of MAA, citrulline and select leukocyte antigens in RA and OA synovial tissues were examined using immunohistochemistry.Circulating and SF anti-MAA antibody concentrations were higher in RA vs OA by 1.5- to 5-fold. IgG (P < 0.001), IgM (P = 0.006) and IgA (P = 0.036) anti-MAA antibodies were higher in paired RA SF than serum, differences not observed for total immunoglobulin, RF or ACPA. In RA synovial tissues, co-localization of MAA with citrulline and CD19+ or CD27+ B cells was demonstrated and was much higher in magnitude than MAA or citrulline co-localization with T cells, monocytes, macrophages or dendritic cells (P < 0.01).Anti-MAA antibodies are present in higher concentrations in the RA joint compared with sera, a finding not observed for other disease-related autoantibodies. Co-localization of MAA and citrulline with mature B cells, coupled with the local enrichment of anti-MAA immune responses, implicates MAA-adduct formation in local autoantibody production.

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Published In

Rheumatology (Oxford, England)

DOI

EISSN

1462-0332

ISSN

1462-0324

Publication Date

October 2017

Volume

56

Issue

10

Start / End Page

1794 / 1803

Related Subject Headings

  • Synovial Fluid
  • Rheumatoid Factor
  • Osteoarthritis
  • Middle Aged
  • Malondialdehyde
  • Male
  • Joints
  • Immunohistochemistry
  • Humans
  • Female
 

Citation

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Mikuls, T. R., Duryee, M. J., Rahman, R., Anderson, D. R., Sayles, H. R., Hollins, A., … Thiele, G. M. (2017). Enrichment of malondialdehyde-acetaldehyde antibody in the rheumatoid arthritis joint. Rheumatology (Oxford, England), 56(10), 1794–1803. https://doi.org/10.1093/rheumatology/kex212
Mikuls, Ted R., Michael J. Duryee, Rafid Rahman, Daniel R. Anderson, Harlan R. Sayles, Andrew Hollins, Kaleb Michaud, et al. “Enrichment of malondialdehyde-acetaldehyde antibody in the rheumatoid arthritis joint.Rheumatology (Oxford, England) 56, no. 10 (October 2017): 1794–1803. https://doi.org/10.1093/rheumatology/kex212.
Mikuls TR, Duryee MJ, Rahman R, Anderson DR, Sayles HR, Hollins A, et al. Enrichment of malondialdehyde-acetaldehyde antibody in the rheumatoid arthritis joint. Rheumatology (Oxford, England). 2017 Oct;56(10):1794–803.
Mikuls, Ted R., et al. “Enrichment of malondialdehyde-acetaldehyde antibody in the rheumatoid arthritis joint.Rheumatology (Oxford, England), vol. 56, no. 10, Oct. 2017, pp. 1794–803. Epmc, doi:10.1093/rheumatology/kex212.
Mikuls TR, Duryee MJ, Rahman R, Anderson DR, Sayles HR, Hollins A, Michaud K, Wolfe F, Thiele GE, Sokolove J, Robinson WH, Lingampalli N, Nicholas AP, Talmon GA, Su K, Zimmerman MC, Klassen LW, Thiele GM. Enrichment of malondialdehyde-acetaldehyde antibody in the rheumatoid arthritis joint. Rheumatology (Oxford, England). 2017 Oct;56(10):1794–1803.
Journal cover image

Published In

Rheumatology (Oxford, England)

DOI

EISSN

1462-0332

ISSN

1462-0324

Publication Date

October 2017

Volume

56

Issue

10

Start / End Page

1794 / 1803

Related Subject Headings

  • Synovial Fluid
  • Rheumatoid Factor
  • Osteoarthritis
  • Middle Aged
  • Malondialdehyde
  • Male
  • Joints
  • Immunohistochemistry
  • Humans
  • Female