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Synergistic effects of HIV and marijuana use on functional brain network organization.

Publication ,  Journal Article
Hall, SA; Lalee, Z; Bell, RP; Towe, SL; Meade, CS
Published in: Progress in neuro-psychopharmacology & biological psychiatry
January 2021

HIV is associated with disruptions in cognition and brain function. Marijuana use is highly prevalent in HIV but its effects on resting brain function in HIV are unknown. Brain function can be characterized by brain activity that is correlated between regions over time, called functional connectivity. Neuropsychiatric disorders are increasingly being characterized by disruptions in such connectivity. We examined the synergistic effects of HIV and marijuana use on functional whole-brain network organization during resting state. Our sample included 78 adults who differed on HIV and marijuana status (19 with co-occurring HIV and marijuana use, 20 HIV-only, 17 marijuana-only, and 22 controls). We examined differences in local and long-range brain network organization using eight graph theoretical metrics: transitivity, local efficiency, within-module degree, modularity, global efficiency, strength, betweenness, and participation coefficient. Local and long-range connectivity were similar between the co-occurring HIV and marijuana use and control groups. In contrast, the HIV-only and marijuana-only groups were both associated with disruptions in brain network organization. These results suggest that marijuana use in HIV may normalize disruptions in brain network organization observed in persons with HIV. However, future work is needed to determine whether this normalization is suggestive of a beneficial or detrimental effect of marijuana on cognitive functioning in HIV.

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Published In

Progress in neuro-psychopharmacology & biological psychiatry

DOI

EISSN

1878-4216

ISSN

0278-5846

Publication Date

January 2021

Volume

104

Start / End Page

110040

Related Subject Headings

  • Young Adult
  • Psychiatry
  • Nerve Net
  • Middle Aged
  • Marijuana Use
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • HIV Infections
  • Female
 

Citation

APA
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MLA
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Hall, S. A., Lalee, Z., Bell, R. P., Towe, S. L., & Meade, C. S. (2021). Synergistic effects of HIV and marijuana use on functional brain network organization. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 104, 110040. https://doi.org/10.1016/j.pnpbp.2020.110040
Hall, Shana A., Zahra Lalee, Ryan P. Bell, Sheri L. Towe, and Christina S. Meade. “Synergistic effects of HIV and marijuana use on functional brain network organization.Progress in Neuro-Psychopharmacology & Biological Psychiatry 104 (January 2021): 110040. https://doi.org/10.1016/j.pnpbp.2020.110040.
Hall SA, Lalee Z, Bell RP, Towe SL, Meade CS. Synergistic effects of HIV and marijuana use on functional brain network organization. Progress in neuro-psychopharmacology & biological psychiatry. 2021 Jan;104:110040.
Hall, Shana A., et al. “Synergistic effects of HIV and marijuana use on functional brain network organization.Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 104, Jan. 2021, p. 110040. Epmc, doi:10.1016/j.pnpbp.2020.110040.
Hall SA, Lalee Z, Bell RP, Towe SL, Meade CS. Synergistic effects of HIV and marijuana use on functional brain network organization. Progress in neuro-psychopharmacology & biological psychiatry. 2021 Jan;104:110040.
Journal cover image

Published In

Progress in neuro-psychopharmacology & biological psychiatry

DOI

EISSN

1878-4216

ISSN

0278-5846

Publication Date

January 2021

Volume

104

Start / End Page

110040

Related Subject Headings

  • Young Adult
  • Psychiatry
  • Nerve Net
  • Middle Aged
  • Marijuana Use
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • HIV Infections
  • Female