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SARS-CoV-2 viral load is associated with increased disease severity and mortality.

Publication ,  Journal Article
Fajnzylber, J; Regan, J; Coxen, K; Corry, H; Wong, C; Rosenthal, A; Worrall, D; Giguel, F; Piechocka-Trocha, A; Atyeo, C; Fischinger, S; Li, Y ...
Published in: Nature communications
October 2020

The relationship between SARS-CoV-2 viral load and risk of disease progression remains largely undefined in coronavirus disease 2019 (COVID-19). Here, we quantify SARS-CoV-2 viral load from participants with a diverse range of COVID-19 disease severity, including those requiring hospitalization, outpatients with mild disease, and individuals with resolved infection. We detected SARS-CoV-2 plasma RNA in 27% of hospitalized participants, and 13% of outpatients diagnosed with COVID-19. Amongst the participants hospitalized with COVID-19, we report that a higher prevalence of detectable SARS-CoV-2 plasma viral load is associated with worse respiratory disease severity, lower absolute lymphocyte counts, and increased markers of inflammation, including C-reactive protein and IL-6. SARS-CoV-2 viral loads, especially plasma viremia, are associated with increased risk of mortality. Our data show that SARS-CoV-2 viral loads may aid in the risk stratification of patients with COVID-19, and therefore its role in disease pathogenesis should be further explored.

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Published In

Nature communications

DOI

EISSN

2041-1723

ISSN

2041-1723

Publication Date

October 2020

Volume

11

Issue

1

Start / End Page

5493

Related Subject Headings

  • Viremia
  • Viral Load
  • Severity of Illness Index
  • SARS-CoV-2
  • RNA, Viral
  • Pneumonia, Viral
  • Pandemics
  • Middle Aged
  • Massachusetts
  • Longitudinal Studies
 

Citation

APA
Chicago
ICMJE
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Fajnzylber, J., Regan, J., Coxen, K., Corry, H., Wong, C., Rosenthal, A., … Massachusetts Consortium for Pathogen Readiness, . (2020). SARS-CoV-2 viral load is associated with increased disease severity and mortality. Nature Communications, 11(1), 5493. https://doi.org/10.1038/s41467-020-19057-5
Fajnzylber, Jesse, James Regan, Kendyll Coxen, Heather Corry, Colline Wong, Alexandra Rosenthal, Daniel Worrall, et al. “SARS-CoV-2 viral load is associated with increased disease severity and mortality.Nature Communications 11, no. 1 (October 2020): 5493. https://doi.org/10.1038/s41467-020-19057-5.
Fajnzylber J, Regan J, Coxen K, Corry H, Wong C, Rosenthal A, et al. SARS-CoV-2 viral load is associated with increased disease severity and mortality. Nature communications. 2020 Oct;11(1):5493.
Fajnzylber, Jesse, et al. “SARS-CoV-2 viral load is associated with increased disease severity and mortality.Nature Communications, vol. 11, no. 1, Oct. 2020, p. 5493. Epmc, doi:10.1038/s41467-020-19057-5.
Fajnzylber J, Regan J, Coxen K, Corry H, Wong C, Rosenthal A, Worrall D, Giguel F, Piechocka-Trocha A, Atyeo C, Fischinger S, Chan A, Flaherty KT, Hall K, Dougan M, Ryan ET, Gillespie E, Chishti R, Li Y, Jilg N, Hanidziar D, Baron RM, Baden L, Tsibris AM, Armstrong KA, Kuritzkes DR, Alter G, Walker BD, Yu X, Li JZ, Massachusetts Consortium for Pathogen Readiness. SARS-CoV-2 viral load is associated with increased disease severity and mortality. Nature communications. 2020 Oct;11(1):5493.

Published In

Nature communications

DOI

EISSN

2041-1723

ISSN

2041-1723

Publication Date

October 2020

Volume

11

Issue

1

Start / End Page

5493

Related Subject Headings

  • Viremia
  • Viral Load
  • Severity of Illness Index
  • SARS-CoV-2
  • RNA, Viral
  • Pneumonia, Viral
  • Pandemics
  • Middle Aged
  • Massachusetts
  • Longitudinal Studies