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The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease.

Publication ,  Journal Article
Kiernan, K; MacIver, NJ
Published in: Front Immunol
2020

Leptin is a critical mediator of the immune response to changes in overall nutrition. Leptin is produced by adipocytes in proportion to adipose tissue mass and is therefore increased in obesity. Despite having a well-described role in regulating systemic metabolism and appetite, leptin displays pleiotropic actions, and it is now clear that leptin has a key role in influencing immune cell function. Indeed, many immune cells have been shown to respond to leptin directly via the leptin receptor, resulting in a largely pro-inflammatory phenotype. Understanding the role of adipose-tissue derived mediators in inflammation is critical to determining the pathophysiology of multiple obesity-associated diseases, such as type 2 diabetes, autoimmune disease, and infection. This review, therefore, focuses on the latest data regarding the role of leptin in modulating inflammation.

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Published In

Front Immunol

DOI

EISSN

1664-3224

Publication Date

2020

Volume

11

Start / End Page

622468

Location

Switzerland

Related Subject Headings

  • Receptors, Leptin
  • Obesity
  • Leptin
  • Infections
  • Humans
  • Diabetes Mellitus, Type 2
  • Autoimmune Diseases
  • Adipose Tissue
  • 3204 Immunology
  • 3105 Genetics
 

Citation

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ICMJE
MLA
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Kiernan, K., & MacIver, N. J. (2020). The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease. Front Immunol, 11, 622468. https://doi.org/10.3389/fimmu.2020.622468
Kiernan, Kaitlin, and Nancie J. MacIver. “The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease.Front Immunol 11 (2020): 622468. https://doi.org/10.3389/fimmu.2020.622468.
Kiernan K, MacIver NJ. The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease. Front Immunol. 2020;11:622468.
Kiernan, Kaitlin, and Nancie J. MacIver. “The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease.Front Immunol, vol. 11, 2020, p. 622468. Pubmed, doi:10.3389/fimmu.2020.622468.
Kiernan K, MacIver NJ. The Role of the Adipokine Leptin in Immune Cell Function in Health and Disease. Front Immunol. 2020;11:622468.

Published In

Front Immunol

DOI

EISSN

1664-3224

Publication Date

2020

Volume

11

Start / End Page

622468

Location

Switzerland

Related Subject Headings

  • Receptors, Leptin
  • Obesity
  • Leptin
  • Infections
  • Humans
  • Diabetes Mellitus, Type 2
  • Autoimmune Diseases
  • Adipose Tissue
  • 3204 Immunology
  • 3105 Genetics