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Global patterns of care in advanced stage mycosis fungoides/Sezary syndrome: a multicenter retrospective follow-up study from the Cutaneous Lymphoma International Consortium.

Publication ,  Journal Article
Quaglino, P; Maule, M; Prince, HM; Porcu, P; Horwitz, S; Duvic, M; Talpur, R; Vermeer, M; Bagot, M; Guitart, J; Papadavid, E; Sanches, JA ...
Published in: Ann Oncol
October 1, 2017

BACKGROUND: Advanced-stage mycosis fungoides (MF)/Sézary syndrome (SS) patients are weighted by an unfavorable prognosis and share an unmet clinical need of effective treatments. International guidelines are available detailing treatment options for the different stages but without recommending treatments in any particular order due to lack of comparative trials. The aims of this second CLIC study were to retrospectively analyze the pattern of care worldwide for advanced-stage MF/SS patients, the distribution of treatments according to geographical areas (USA versus non-USA), and whether the heterogeneity of approaches has potential impact on survival. PATIENTS AND METHODS: This study included 853 patients from 21 specialist centers (14 European, 4 USA, 1 each Australian, Brazilian, and Japanese). RESULTS: Heterogeneity of treatment approaches was found, with up to 24 different modalities or combinations used as first-line and 36% of patients receiving four or more treatments. Stage IIB disease was most frequently treated by total-skin-electron-beam radiotherapy, bexarotene and gemcitabine; erythrodermic and SS patients by extracorporeal photochemotherapy, and stage IVA2 by polychemotherapy. Significant differences were found between USA and non-USA centers, with bexarotene, photopheresis and histone deacetylase inhibitors most frequently prescribed for first-line treatment in USA while phototherapy, interferon, chlorambucil and gemcitabine in non-USA centers. These differences did not significantly impact on survival. However, when considering death and therapy change as competing risk events and the impact of first treatment line on both events, both monochemotherapy (SHR = 2.07) and polychemotherapy (SHR = 1.69) showed elevated relative risks. CONCLUSION: This large multicenter retrospective study shows that there exist a large treatment heterogeneity in advanced MF/SS and differences between USA and non-USA centers but these were not related to survival, while our data reveal that chemotherapy as first treatment is associated with a higher risk of death and/or change of therapy and thus other therapeutic options should be preferable as first treatment approach.

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Published In

Ann Oncol

DOI

EISSN

1569-8041

Publication Date

October 1, 2017

Volume

28

Issue

10

Start / End Page

2517 / 2525

Location

England

Related Subject Headings

  • Young Adult
  • United States
  • Sezary Syndrome
  • Retrospective Studies
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Mycosis Fungoides
  • Middle Aged
  • Medical Oncology
  • Male
 

Citation

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Quaglino, P., Maule, M., Prince, H. M., Porcu, P., Horwitz, S., Duvic, M., … Kim, Y. (2017). Global patterns of care in advanced stage mycosis fungoides/Sezary syndrome: a multicenter retrospective follow-up study from the Cutaneous Lymphoma International Consortium. Ann Oncol, 28(10), 2517–2525. https://doi.org/10.1093/annonc/mdx352
Quaglino, P., M. Maule, H. M. Prince, P. Porcu, S. Horwitz, M. Duvic, R. Talpur, et al. “Global patterns of care in advanced stage mycosis fungoides/Sezary syndrome: a multicenter retrospective follow-up study from the Cutaneous Lymphoma International Consortium.Ann Oncol 28, no. 10 (October 1, 2017): 2517–25. https://doi.org/10.1093/annonc/mdx352.
Quaglino, P., et al. “Global patterns of care in advanced stage mycosis fungoides/Sezary syndrome: a multicenter retrospective follow-up study from the Cutaneous Lymphoma International Consortium.Ann Oncol, vol. 28, no. 10, Oct. 2017, pp. 2517–25. Pubmed, doi:10.1093/annonc/mdx352.
Quaglino P, Maule M, Prince HM, Porcu P, Horwitz S, Duvic M, Talpur R, Vermeer M, Bagot M, Guitart J, Papadavid E, Sanches JA, Hodak E, Sugaya M, Berti E, Ortiz-Romero P, Pimpinelli N, Servitje O, Pileri A, Zinzani PL, Estrach T, Knobler R, Stadler R, Fierro MT, Alberti Violetti S, Amitay-Laish I, Antoniou C, Astrua C, Chaganti S, Child F, Combalia A, Fabbro S, Fava P, Grandi V, Jonak C, Martinez-Escala E, Kheterpal M, Kim EJ, McCormack C, Miyagaki T, Miyashiro D, Morris S, Muniesa C, Nikolaou V, Ognibene G, Onida F, Osella-Abate S, Porkert S, Postigo-Llorente C, Ram-Wolff C, Ribero S, Rogers K, Sanlorenzo M, Stranzenbach R, Spaccarelli N, Stevens A, Zugna D, Rook AH, Geskin LJ, Willemze R, Whittaker S, Hoppe R, Scarisbrick J, Kim Y. Global patterns of care in advanced stage mycosis fungoides/Sezary syndrome: a multicenter retrospective follow-up study from the Cutaneous Lymphoma International Consortium. Ann Oncol. 2017 Oct 1;28(10):2517–2525.
Journal cover image

Published In

Ann Oncol

DOI

EISSN

1569-8041

Publication Date

October 1, 2017

Volume

28

Issue

10

Start / End Page

2517 / 2525

Location

England

Related Subject Headings

  • Young Adult
  • United States
  • Sezary Syndrome
  • Retrospective Studies
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Mycosis Fungoides
  • Middle Aged
  • Medical Oncology
  • Male