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Interaction of greenness and polygenic risk score of Alzheimer's disease on risk of cognitive impairment.

Publication ,  Journal Article
Jin, X; Shu, C; Zeng, Y; Liang, L; Ji, JS
Published in: Sci Total Environ
November 20, 2021

Studies have shown contact with nature has positive psychological, neurological, and cognitive benefits. Whether the built environment can affect genetic predisposition of Alzheimer's disease (AD) should be explored. We aimed to examine whether greenness around the residential environment can modify the effect of genetic AD risk on cognitive function. We used a genetic sub-study of the Chinese Longitudinal Healthy Longevity Survey including 1199 older adults (mean age: 100.3 ± 3.4 years) aged 90 years old or older. We used Polygenic Risk Score (PRS) to quantify the genetic AD risk and two types of measurements based on Normalized Difference Vegetation Index (NDVI) to access the residential greenness (contemporaneous and annual average NDVI). Contemporaneous NDVI values were the NDVI value collected at the corresponding survey, and the annual average NDVI was the average value of NDVI during the year before the corresponding survey. We defined cognitive impairment as having a Mini-Mental State Examination score below 25. In the multivariable logistics regression models, contemporaneous NDVI and genetic AD risk were associated with cognitive impairment. Among those with low genetic AD risk, the risk of cognitive impairment was lower in those living around higher greenness (contemporaneous NDVI OR: 0.55, 95% CI: [0.34, 0.86]; Pinteraction: 0.071; annual average NDVI OR: 0.49, 95% CI: [0.31, 0.79]; Pinteraction: 0.040). We did not observe significant associations between greenness and cognitive impairment among those with high genetic AD risk. Prevention efforts using PRS warrant a higher granularity of environmental exposures and biological etiology data.

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Published In

Sci Total Environ

DOI

EISSN

1879-1026

Publication Date

November 20, 2021

Volume

796

Start / End Page

148767

Location

Netherlands

Related Subject Headings

  • Risk Factors
  • Longitudinal Studies
  • Humans
  • Environmental Sciences
  • Cognitive Dysfunction
  • Built Environment
  • Alzheimer Disease
  • Aged, 80 and over
  • Aged
 

Citation

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Jin, X., Shu, C., Zeng, Y., Liang, L., & Ji, J. S. (2021). Interaction of greenness and polygenic risk score of Alzheimer's disease on risk of cognitive impairment. Sci Total Environ, 796, 148767. https://doi.org/10.1016/j.scitotenv.2021.148767
Jin, Xurui, Chang Shu, Yi Zeng, Liming Liang, and John S. Ji. “Interaction of greenness and polygenic risk score of Alzheimer's disease on risk of cognitive impairment.Sci Total Environ 796 (November 20, 2021): 148767. https://doi.org/10.1016/j.scitotenv.2021.148767.
Jin X, Shu C, Zeng Y, Liang L, Ji JS. Interaction of greenness and polygenic risk score of Alzheimer's disease on risk of cognitive impairment. Sci Total Environ. 2021 Nov 20;796:148767.
Jin, Xurui, et al. “Interaction of greenness and polygenic risk score of Alzheimer's disease on risk of cognitive impairment.Sci Total Environ, vol. 796, Nov. 2021, p. 148767. Pubmed, doi:10.1016/j.scitotenv.2021.148767.
Jin X, Shu C, Zeng Y, Liang L, Ji JS. Interaction of greenness and polygenic risk score of Alzheimer's disease on risk of cognitive impairment. Sci Total Environ. 2021 Nov 20;796:148767.
Journal cover image

Published In

Sci Total Environ

DOI

EISSN

1879-1026

Publication Date

November 20, 2021

Volume

796

Start / End Page

148767

Location

Netherlands

Related Subject Headings

  • Risk Factors
  • Longitudinal Studies
  • Humans
  • Environmental Sciences
  • Cognitive Dysfunction
  • Built Environment
  • Alzheimer Disease
  • Aged, 80 and over
  • Aged