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Metabolic decisions in development and disease-a Keystone Symposia report.

Publication ,  Journal Article
Cable, J; Pourquié, O; Wellen, KE; Finley, LWS; Aulehla, A; Gould, AP; Teleman, A; Tu, WB; Garrett, WS; Miguel-Aliaga, I; Perrimon, N; Wei, W ...
Published in: Annals of the New York Academy of Sciences
December 2021

There is an increasing appreciation for the role of metabolism in cell signaling and cell decision making. Precise metabolic control is essential in development, as evident by the disorders caused by mutations in metabolic enzymes. The metabolic profile of cells is often cell-type specific, changing as cells differentiate or during tumorigenesis. Recent evidence has shown that changes in metabolism are not merely a consequence of changes in cell state but that metabolites can serve to promote and/or inhibit these changes. Metabolites can link metabolic pathways with cell signaling pathways via several mechanisms, for example, by serving as substrates for protein post-translational modifications, by affecting enzyme activity via allosteric mechanisms, or by altering epigenetic markers. Unraveling the complex interactions governing metabolism, gene expression, and protein activity that ultimately govern a cell's fate will require new tools and interactions across disciplines. On March 24 and 25, 2021, experts in cell metabolism, developmental biology, and human disease met virtually for the Keystone eSymposium, "Metabolic Decisions in Development and Disease." The discussions explored how metabolites impact cellular and developmental decisions in a diverse range of model systems used to investigate normal development, developmental disorders, dietary effects, and cancer-mediated changes in metabolism.

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Published In

Annals of the New York Academy of Sciences

DOI

EISSN

1749-6632

ISSN

0077-8923

Publication Date

December 2021

Volume

1506

Issue

1

Start / End Page

55 / 73

Related Subject Headings

  • Signal Transduction
  • Research Report
  • Neoplasms
  • Metabolic Networks and Pathways
  • Metabolic Diseases
  • Humans
  • Human Development
  • General Science & Technology
  • Epigenesis, Genetic
  • Congresses as Topic
 

Citation

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Cable, J., Pourquié, O., Wellen, K. E., Finley, L. W. S., Aulehla, A., Gould, A. P., … Christofk, H. (2021). Metabolic decisions in development and disease-a Keystone Symposia report. Annals of the New York Academy of Sciences, 1506(1), 55–73. https://doi.org/10.1111/nyas.14678
Cable, Jennifer, Olivier Pourquié, Kathryn E. Wellen, Lydia W. S. Finley, Alexander Aulehla, Alex P. Gould, Aurelio Teleman, et al. “Metabolic decisions in development and disease-a Keystone Symposia report.Annals of the New York Academy of Sciences 1506, no. 1 (December 2021): 55–73. https://doi.org/10.1111/nyas.14678.
Cable J, Pourquié O, Wellen KE, Finley LWS, Aulehla A, Gould AP, et al. Metabolic decisions in development and disease-a Keystone Symposia report. Annals of the New York Academy of Sciences. 2021 Dec;1506(1):55–73.
Cable, Jennifer, et al. “Metabolic decisions in development and disease-a Keystone Symposia report.Annals of the New York Academy of Sciences, vol. 1506, no. 1, Dec. 2021, pp. 55–73. Epmc, doi:10.1111/nyas.14678.
Cable J, Pourquié O, Wellen KE, Finley LWS, Aulehla A, Gould AP, Teleman A, Tu WB, Garrett WS, Miguel-Aliaga I, Perrimon N, Hooper LV, Walhout AJM, Wei W, Alexandrov T, Erez A, Ralser M, Rabinowitz JD, Hemalatha A, Gutiérrez-Pérez P, Chandel NS, Rutter J, Locasale JW, Landoni JC, Christofk H. Metabolic decisions in development and disease-a Keystone Symposia report. Annals of the New York Academy of Sciences. 2021 Dec;1506(1):55–73.
Journal cover image

Published In

Annals of the New York Academy of Sciences

DOI

EISSN

1749-6632

ISSN

0077-8923

Publication Date

December 2021

Volume

1506

Issue

1

Start / End Page

55 / 73

Related Subject Headings

  • Signal Transduction
  • Research Report
  • Neoplasms
  • Metabolic Networks and Pathways
  • Metabolic Diseases
  • Humans
  • Human Development
  • General Science & Technology
  • Epigenesis, Genetic
  • Congresses as Topic