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Clinical characteristics and prognostic factors of 70 patients with Sézary syndrome: a single-institutional experience at Moffitt cancer center.

Publication ,  Journal Article
Zhang, Y; Seminario-Vidal, L; Varnadoe, C; Lu, Y; Dong, N; Salamanca, C; Whiddon, S; Bennett, J; Hargis, R; Liu, H; Montejo, M; Hussaini, M ...
Published in: Leuk Lymphoma
January 2022

Sézary syndrome (SS) is a rare and aggressive leukemic variant of cutaneous T-cell lymphoma, with a median overall survival (OS) rate of 2-4 years. Few studies have described the clinical outcome of SS patients since 2012. We retrospectively analyzed 70 patients diagnosed with SS treated at a high-volume tertiary cancer center between 2000 and 2018. Overall survival at 1 and 5 years was 84.1% and 50.7%, respectively. Univariate analyses identified older age (>65 years) and male sex as poor prognostic factors. Five patients presented with circulating large granular lymphocytic proliferation and had a favorable prognosis. Targeted therapies were effective in treating refractory/relapsed SS patients with a durable response. Therapeutic advancements and the comprehensive treatments used in a multidisciplinary clinic improved OS rates.

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Published In

Leuk Lymphoma

DOI

EISSN

1029-2403

Publication Date

January 2022

Volume

63

Issue

1

Start / End Page

109 / 116

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Sezary Syndrome
  • Retrospective Studies
  • Prognosis
  • Mycosis Fungoides
  • Male
  • Lymphoma, T-Cell, Cutaneous
  • Immunology
  • Humans
  • 3201 Cardiovascular medicine and haematology
 

Citation

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Zhang, Y., Seminario-Vidal, L., Varnadoe, C., Lu, Y., Dong, N., Salamanca, C., … Sokol, L. (2022). Clinical characteristics and prognostic factors of 70 patients with Sézary syndrome: a single-institutional experience at Moffitt cancer center. Leuk Lymphoma, 63(1), 109–116. https://doi.org/10.1080/10428194.2021.1971218
Zhang, Yumeng, Lucia Seminario-Vidal, Christa Varnadoe, Yuanyuan Lu, Ning Dong, Christopher Salamanca, Shannen Whiddon, et al. “Clinical characteristics and prognostic factors of 70 patients with Sézary syndrome: a single-institutional experience at Moffitt cancer center.Leuk Lymphoma 63, no. 1 (January 2022): 109–16. https://doi.org/10.1080/10428194.2021.1971218.
Zhang Y, Seminario-Vidal L, Varnadoe C, Lu Y, Dong N, Salamanca C, et al. Clinical characteristics and prognostic factors of 70 patients with Sézary syndrome: a single-institutional experience at Moffitt cancer center. Leuk Lymphoma. 2022 Jan;63(1):109–16.
Zhang, Yumeng, et al. “Clinical characteristics and prognostic factors of 70 patients with Sézary syndrome: a single-institutional experience at Moffitt cancer center.Leuk Lymphoma, vol. 63, no. 1, Jan. 2022, pp. 109–16. Pubmed, doi:10.1080/10428194.2021.1971218.
Zhang Y, Seminario-Vidal L, Varnadoe C, Lu Y, Dong N, Salamanca C, Whiddon S, Bennett J, Hargis R, Liu H, Montejo M, Hussaini M, Harro C, Messina J, Benson K, Pinilla-Ibarz J, Conejo-Garcia J, Sokol L. Clinical characteristics and prognostic factors of 70 patients with Sézary syndrome: a single-institutional experience at Moffitt cancer center. Leuk Lymphoma. 2022 Jan;63(1):109–116.

Published In

Leuk Lymphoma

DOI

EISSN

1029-2403

Publication Date

January 2022

Volume

63

Issue

1

Start / End Page

109 / 116

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Sezary Syndrome
  • Retrospective Studies
  • Prognosis
  • Mycosis Fungoides
  • Male
  • Lymphoma, T-Cell, Cutaneous
  • Immunology
  • Humans
  • 3201 Cardiovascular medicine and haematology