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Exercise and Diet: Uncovering Prospective Mediators of Skeletal Fragility in Bone and Marrow Adipose Tissue.

Publication ,  Journal Article
Little-Letsinger, SE; Pagnotti, GM; McGrath, C; Styner, M
Published in: Current osteoporosis reports
December 2020

To highlight recent basic, translational, and clinical works demonstrating exercise and diet regulation of marrow adipose tissue (MAT) and bone and how this informs current understanding of the relationship between marrow adiposity and musculoskeletal health.Marrow adipocytes accumulate in the bone in the setting of not only hypercaloric intake (calorie excess; e.g., diet-induced obesity) but also with hypocaloric intake (calorie restriction; e.g., anorexia), despite the fact that these states affect bone differently. With hypercaloric intake, bone quantity is largely unaffected, whereas with hypocaloric intake, bone quantity and quality are greatly diminished. Voluntary running exercise in rodents was found to lower MAT and promote bone in eucaloric and hypercaloric states, while degrading bone in hypocaloric states, suggesting differential modulation of MAT and bone, dependent upon whole-body energy status. Energy status alters bone metabolism and bioenergetics via substrate availability or excess, which plays a key role in the response of bone and MAT to mechanical stimuli. Marrow adipose tissue (MAT) is a fat depot with a potential role in-as well as responsivity to-whole-body energy metabolism. Understanding the localized function of this depot in bone cell bioenergetics and substrate storage, principally in the exercised state, will aid to uncover putative therapeutic targets for skeletal fragility.

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Published In

Current osteoporosis reports

DOI

EISSN

1544-2241

ISSN

1544-1873

Publication Date

December 2020

Volume

18

Issue

6

Start / End Page

774 / 789

Related Subject Headings

  • Humans
  • Exercise
  • Energy Metabolism
  • Endocrinology & Metabolism
  • Diet
  • Bone and Bones
  • Bone Marrow
  • Bone Density
  • Animals
  • Adipose Tissue
 

Citation

APA
Chicago
ICMJE
MLA
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Little-Letsinger, S. E., Pagnotti, G. M., McGrath, C., & Styner, M. (2020). Exercise and Diet: Uncovering Prospective Mediators of Skeletal Fragility in Bone and Marrow Adipose Tissue. Current Osteoporosis Reports, 18(6), 774–789. https://doi.org/10.1007/s11914-020-00634-y
Little-Letsinger, Sarah E., Gabriel M. Pagnotti, Cody McGrath, and Maya Styner. “Exercise and Diet: Uncovering Prospective Mediators of Skeletal Fragility in Bone and Marrow Adipose Tissue.Current Osteoporosis Reports 18, no. 6 (December 2020): 774–89. https://doi.org/10.1007/s11914-020-00634-y.
Little-Letsinger SE, Pagnotti GM, McGrath C, Styner M. Exercise and Diet: Uncovering Prospective Mediators of Skeletal Fragility in Bone and Marrow Adipose Tissue. Current osteoporosis reports. 2020 Dec;18(6):774–89.
Little-Letsinger, Sarah E., et al. “Exercise and Diet: Uncovering Prospective Mediators of Skeletal Fragility in Bone and Marrow Adipose Tissue.Current Osteoporosis Reports, vol. 18, no. 6, Dec. 2020, pp. 774–89. Epmc, doi:10.1007/s11914-020-00634-y.
Little-Letsinger SE, Pagnotti GM, McGrath C, Styner M. Exercise and Diet: Uncovering Prospective Mediators of Skeletal Fragility in Bone and Marrow Adipose Tissue. Current osteoporosis reports. 2020 Dec;18(6):774–789.
Journal cover image

Published In

Current osteoporosis reports

DOI

EISSN

1544-2241

ISSN

1544-1873

Publication Date

December 2020

Volume

18

Issue

6

Start / End Page

774 / 789

Related Subject Headings

  • Humans
  • Exercise
  • Energy Metabolism
  • Endocrinology & Metabolism
  • Diet
  • Bone and Bones
  • Bone Marrow
  • Bone Density
  • Animals
  • Adipose Tissue