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The oxidative stress response.

Publication ,  Journal Article
Camhi, SL; Lee, P; Choi, AM
Published in: New horizons (Baltimore, Md.)
May 1995

Oxidative stress resulting from toxic effects of reactive oxygen species (ROS) plays an important role in the pathogenesis of a variety of diseases and important biological processes. Toxic effects of these ROS, including the superoxide and hydroxyl radicals, and hydrogen peroxide can cause cellular damage by oxidizing nucleic acids, proteins, and membrane lipids. While the chemical reactions involved in the generation and detoxification of ROS have been studied in great detail, little is known about the cellular and molecular responses to oxidative stress in mammalian cells. This article discusses some of the major aspects of these molecular responses, including alterations in the gene expression of antioxidant enzymes, stress-response genes, and cytokines. The regulatory mechanisms that control this genetic response are highly complex, involving activation of transcription factors and signal transduction pathways. Further characterization of the mechanisms that regulate these molecular responses is essential for understanding the physiologic function of the responses and for the development of new therapeutic modalities to defend and/or adapt to oxidant injury.

Published In

New horizons (Baltimore, Md.)

ISSN

1063-7389

Publication Date

May 1995

Volume

3

Issue

2

Start / End Page

170 / 182

Related Subject Headings

  • Transcription, Genetic
  • Transcription Factors
  • Superoxide Dismutase
  • Stress, Physiological
  • Signal Transduction
  • Reactive Oxygen Species
  • Oxidative Stress
  • Oxidation-Reduction
  • Nuclear Proteins
  • Molecular Sequence Data
 

Citation

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ICMJE
MLA
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Camhi, S. L., Lee, P., & Choi, A. M. (1995). The oxidative stress response. New Horizons (Baltimore, Md.), 3(2), 170–182.
Camhi, S. L., P. Lee, and A. M. Choi. “The oxidative stress response.New Horizons (Baltimore, Md.) 3, no. 2 (May 1995): 170–82.
Camhi SL, Lee P, Choi AM. The oxidative stress response. New horizons (Baltimore, Md). 1995 May;3(2):170–82.
Camhi, S. L., et al. “The oxidative stress response.New Horizons (Baltimore, Md.), vol. 3, no. 2, May 1995, pp. 170–82.
Camhi SL, Lee P, Choi AM. The oxidative stress response. New horizons (Baltimore, Md). 1995 May;3(2):170–182.

Published In

New horizons (Baltimore, Md.)

ISSN

1063-7389

Publication Date

May 1995

Volume

3

Issue

2

Start / End Page

170 / 182

Related Subject Headings

  • Transcription, Genetic
  • Transcription Factors
  • Superoxide Dismutase
  • Stress, Physiological
  • Signal Transduction
  • Reactive Oxygen Species
  • Oxidative Stress
  • Oxidation-Reduction
  • Nuclear Proteins
  • Molecular Sequence Data