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Lamotrigine for bipolar disorder and comorbid cocaine dependence: a replication and extension study.

Publication ,  Journal Article
Brown, ES; Perantie, DC; Dhanani, N; Beard, L; Orsulak, P; Rush, AJ
Published in: J Affect Disord
July 2006

BACKGROUND: Bipolar disorder (BPD) is associated with high rates of substance abuse. We previously reported favorable results with lamotrigine in 30 patients with BPD and cocaine dependence. This report examines lamotrigine therapy in an additional 32 cocaine dependent patients. Data on these 32 participants are presented as a replication study. In addition, we extend the previous findings by combining data from both groups, and by exploring predictors of response. METHOD: Participants received a baseline evaluation and assessment for up to 36weeks with the 17-item Hamilton Rating Scale for Depression (HRSD(17)), Young Mania Rating Scale (YMRS), Brief Psychiatric Rating Scale (BPRS(18)), and Cocaine Craving Questionnaire (CCQ). Urine samples were obtained, and participants reported drug use during the previous week. RESULTS: In the replication sample (n=32), significant improvements were observed in HRSD(17), YMRS, BPRS(18), and CCQ (baseline to exit), as well as on dollars/week spent on cocaine. In the extension study, the original sample (n=30) and the replication sample (n=32) were combined for a total of 62 participants in the intent-to-treat sample. HRSD(17), YMRS, BPRS(18), and CCQ scores, as well as dollars spent on cocaine, decreased significantly. LIMITATIONS: The study has an open-label, uncontrolled design. CONCLUSION: Lamotrigine treatment was associated with significant improvements in mood, drug craving, and drug use. Controlled trials are needed.

Duke Scholars

Published In

J Affect Disord

DOI

ISSN

0165-0327

Publication Date

July 2006

Volume

93

Issue

1-3

Start / End Page

219 / 222

Location

Netherlands

Related Subject Headings

  • Triazines
  • Treatment Outcome
  • Surveys and Questionnaires
  • Substance Withdrawal Syndrome
  • Reproducibility of Results
  • Psychiatry
  • Personality Inventory
  • Motivation
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Brown, E. S., Perantie, D. C., Dhanani, N., Beard, L., Orsulak, P., & Rush, A. J. (2006). Lamotrigine for bipolar disorder and comorbid cocaine dependence: a replication and extension study. J Affect Disord, 93(1–3), 219–222. https://doi.org/10.1016/j.jad.2006.02.001
Brown, E Sherwood, Dana C. Perantie, Nafisa Dhanani, Laura Beard, Paul Orsulak, and A John Rush. “Lamotrigine for bipolar disorder and comorbid cocaine dependence: a replication and extension study.J Affect Disord 93, no. 1–3 (July 2006): 219–22. https://doi.org/10.1016/j.jad.2006.02.001.
Brown ES, Perantie DC, Dhanani N, Beard L, Orsulak P, Rush AJ. Lamotrigine for bipolar disorder and comorbid cocaine dependence: a replication and extension study. J Affect Disord. 2006 Jul;93(1–3):219–22.
Brown, E. Sherwood, et al. “Lamotrigine for bipolar disorder and comorbid cocaine dependence: a replication and extension study.J Affect Disord, vol. 93, no. 1–3, July 2006, pp. 219–22. Pubmed, doi:10.1016/j.jad.2006.02.001.
Brown ES, Perantie DC, Dhanani N, Beard L, Orsulak P, Rush AJ. Lamotrigine for bipolar disorder and comorbid cocaine dependence: a replication and extension study. J Affect Disord. 2006 Jul;93(1–3):219–222.
Journal cover image

Published In

J Affect Disord

DOI

ISSN

0165-0327

Publication Date

July 2006

Volume

93

Issue

1-3

Start / End Page

219 / 222

Location

Netherlands

Related Subject Headings

  • Triazines
  • Treatment Outcome
  • Surveys and Questionnaires
  • Substance Withdrawal Syndrome
  • Reproducibility of Results
  • Psychiatry
  • Personality Inventory
  • Motivation
  • Middle Aged
  • Male