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Stability of plasma GABA at four-year follow-up in patients with primary unipolar depression.

Publication ,  Journal Article
Petty, F; Kramer, GL; Fulton, M; Davis, L; Rush, AJ
Published in: Biol Psychiatry
June 1, 1995

The biology of mood disorders involves gamma-aminobutyric acid (GABA), a neurotransmitter whose levels in plasma likely reflect brain GABA activity. Previous research has shown that a subset of patients with primary unipolar major depression have low plasma GABA levels, which parallels findings from studies of cerebrospinal fluid. We have completed a 4-year follow-up on 46 male patients with primary unipolar depression. Plasma levels of GABA were stable over this time. For the group, mean plasma GABA levels on follow-up did not change significantly from entry levels. Plasma GABA levels measured on follow-up were significantly (p < .001) correlated with entry levels. Patients with low plasma GABA levels (< 100 pmol/ml) on entry into the study were likely to remain low on follow-up, and patients with plasma GABA levels in the control range (> or = 100 pmol/ml) at entry similarly remained in this category (chi 2 = 7.23, p = .007). This was true whether or not the patient had recovered from depression on follow-up. Levels of plasma GABA did not significantly correlate with severity of depression at either entry (p = .40) or follow-up (p = .52), nor was there a significant correlation between change in plasma GABA and change in the 17-item Hamilton Depression Rating Scale score from entry to follow-up (p = .89). These data are consistent with the notion that plasma GABA is independent of clinical state in patients with primary unipolar depression. Low plasma GABA may be a trait marker of illness in a subset of patients with mood disorder.

Duke Scholars

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

June 1, 1995

Volume

37

Issue

11

Start / End Page

806 / 810

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Psychiatry
  • Personality Inventory
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Depressive Disorder
  • Aged
  • Adult
 

Citation

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MLA
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Petty, F., Kramer, G. L., Fulton, M., Davis, L., & Rush, A. J. (1995). Stability of plasma GABA at four-year follow-up in patients with primary unipolar depression. Biol Psychiatry, 37(11), 806–810. https://doi.org/10.1016/0006-3223(94)00226-S
Petty, F., G. L. Kramer, M. Fulton, L. Davis, and A. J. Rush. “Stability of plasma GABA at four-year follow-up in patients with primary unipolar depression.Biol Psychiatry 37, no. 11 (June 1, 1995): 806–10. https://doi.org/10.1016/0006-3223(94)00226-S.
Petty F, Kramer GL, Fulton M, Davis L, Rush AJ. Stability of plasma GABA at four-year follow-up in patients with primary unipolar depression. Biol Psychiatry. 1995 Jun 1;37(11):806–10.
Petty, F., et al. “Stability of plasma GABA at four-year follow-up in patients with primary unipolar depression.Biol Psychiatry, vol. 37, no. 11, June 1995, pp. 806–10. Pubmed, doi:10.1016/0006-3223(94)00226-S.
Petty F, Kramer GL, Fulton M, Davis L, Rush AJ. Stability of plasma GABA at four-year follow-up in patients with primary unipolar depression. Biol Psychiatry. 1995 Jun 1;37(11):806–810.
Journal cover image

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

June 1, 1995

Volume

37

Issue

11

Start / End Page

806 / 810

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Psychiatry
  • Personality Inventory
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Depressive Disorder
  • Aged
  • Adult