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The effects of extended evaluation on depressive symptoms in children and adolescents.

Publication ,  Journal Article
Rintelmann, JW; Emslie, GJ; Rush, AJ; Varghese, T; Gullion, CM; Kowatch, RA; Hughes, CW
Published in: J Affect Disord
November 25, 1996

A sample of 137 child and adolescent outpatients with major depressive disorder were examined to identify baseline clinical characteristics that predicted symptom severity at the end of a 3-week evaluation period and to determine whether change in symptom severity between week 1 and week 2 predicted symptom severity at week three. Subjects underwent three consecutive weekly evaluations prior to being considered for entry into a double-blind, placebo-controlled treatment trial of fluoxetine. Results indicated that the combination of age, social functioning, family history, Children's Depressive Rating Scale-Revised (CDRS-R) (Poznanski et al. (1985) Psychopharmacol. Bull. 21, 979-989) total score at visit one, and percent change in symptom severity between visit one and visit two were predictors of symptom severity at visit three. These findings suggest that (1) subjects should not be excluded from randomized controlled clinical treatment trials based solely on improvement of symptom severity between visits and (2) an extended evaluation period is warranted, especially for adolescents whose symptom severity tends to fluctuate from week to week.

Duke Scholars

Published In

J Affect Disord

DOI

ISSN

0165-0327

Publication Date

November 25, 1996

Volume

41

Issue

2

Start / End Page

149 / 156

Location

Netherlands

Related Subject Headings

  • Recurrence
  • Psychometrics
  • Psychiatry
  • Personality Assessment
  • Male
  • Humans
  • Follow-Up Studies
  • Fluoxetine
  • Female
  • Double-Blind Method
 

Citation

APA
Chicago
ICMJE
MLA
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Rintelmann, J. W., Emslie, G. J., Rush, A. J., Varghese, T., Gullion, C. M., Kowatch, R. A., & Hughes, C. W. (1996). The effects of extended evaluation on depressive symptoms in children and adolescents. J Affect Disord, 41(2), 149–156. https://doi.org/10.1016/s0165-0327(96)00084-5
Rintelmann, J. W., G. J. Emslie, A. J. Rush, T. Varghese, C. M. Gullion, R. A. Kowatch, and C. W. Hughes. “The effects of extended evaluation on depressive symptoms in children and adolescents.J Affect Disord 41, no. 2 (November 25, 1996): 149–56. https://doi.org/10.1016/s0165-0327(96)00084-5.
Rintelmann JW, Emslie GJ, Rush AJ, Varghese T, Gullion CM, Kowatch RA, et al. The effects of extended evaluation on depressive symptoms in children and adolescents. J Affect Disord. 1996 Nov 25;41(2):149–56.
Rintelmann, J. W., et al. “The effects of extended evaluation on depressive symptoms in children and adolescents.J Affect Disord, vol. 41, no. 2, Nov. 1996, pp. 149–56. Pubmed, doi:10.1016/s0165-0327(96)00084-5.
Rintelmann JW, Emslie GJ, Rush AJ, Varghese T, Gullion CM, Kowatch RA, Hughes CW. The effects of extended evaluation on depressive symptoms in children and adolescents. J Affect Disord. 1996 Nov 25;41(2):149–156.
Journal cover image

Published In

J Affect Disord

DOI

ISSN

0165-0327

Publication Date

November 25, 1996

Volume

41

Issue

2

Start / End Page

149 / 156

Location

Netherlands

Related Subject Headings

  • Recurrence
  • Psychometrics
  • Psychiatry
  • Personality Assessment
  • Male
  • Humans
  • Follow-Up Studies
  • Fluoxetine
  • Female
  • Double-Blind Method