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Daily process methodology for measuring earlier antidepressant response.

Publication ,  Journal Article
Lenderking, WR; Hu, M; Tennen, H; Cappelleri, JC; Petrie, CD; Rush, AJ
Published in: Contemp Clin Trials
November 2008

OBJECTIVE: Rapid onset of therapeutic action for antidepressant medication represents a major area of unmet medical need, and any such effects have been difficult to detect using standard study designs and measurement strategies. We conducted a randomized, open-label study with blinded raters using daily process assessment vs. standard weekly assessment to answer the following study questions: 1) is it possible to detect an antidepressant response more rapidly with daily assessment than with standard assessment approaches? 2) what is the burden of daily assessment on participants relative to standard clinical assessments? and 3) does the process of completing daily assessments have any effect on clinic-based assessments such as the Hamilton Depression Rating Scale (HAM-D)? METHOD: Seventy-eight outpatients with major depressive disorder who received open-label fluoxetine were randomized to standard weekly clinic assessment or standard weekly clinic assessment plus daily assessment, and were followed for 28 days. Data were collected between September, 2002 and August, 2003. RESULTS: Daily assessment appeared to have no effect on 17-item HAM-D or MADRS scores obtained in the clinic. Survival analyses revealed that daily diaries detected therapeutic effects more quickly than did standard weekly clinic assessments, across most endpoints. Perceived burden of study participation was not significantly increased by daily diary completion, nor reflected in higher dropout rates. CONCLUSION: Daily process assessment improves the ability to detect an early antidepressant response.

Duke Scholars

Published In

Contemp Clin Trials

DOI

EISSN

1559-2030

Publication Date

November 2008

Volume

29

Issue

6

Start / End Page

867 / 877

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Single-Blind Method
  • Research Design
  • Public Health
  • Psychometrics
  • Prospective Studies
  • Neuropsychological Tests
  • Models, Psychological
  • Middle Aged
 

Citation

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Lenderking, W. R., Hu, M., Tennen, H., Cappelleri, J. C., Petrie, C. D., & Rush, A. J. (2008). Daily process methodology for measuring earlier antidepressant response. Contemp Clin Trials, 29(6), 867–877. https://doi.org/10.1016/j.cct.2008.05.012
Lenderking, William R., Mingxiu Hu, Howard Tennen, Joseph C. Cappelleri, Charles D. Petrie, and A John Rush. “Daily process methodology for measuring earlier antidepressant response.Contemp Clin Trials 29, no. 6 (November 2008): 867–77. https://doi.org/10.1016/j.cct.2008.05.012.
Lenderking WR, Hu M, Tennen H, Cappelleri JC, Petrie CD, Rush AJ. Daily process methodology for measuring earlier antidepressant response. Contemp Clin Trials. 2008 Nov;29(6):867–77.
Lenderking, William R., et al. “Daily process methodology for measuring earlier antidepressant response.Contemp Clin Trials, vol. 29, no. 6, Nov. 2008, pp. 867–77. Pubmed, doi:10.1016/j.cct.2008.05.012.
Lenderking WR, Hu M, Tennen H, Cappelleri JC, Petrie CD, Rush AJ. Daily process methodology for measuring earlier antidepressant response. Contemp Clin Trials. 2008 Nov;29(6):867–877.
Journal cover image

Published In

Contemp Clin Trials

DOI

EISSN

1559-2030

Publication Date

November 2008

Volume

29

Issue

6

Start / End Page

867 / 877

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Single-Blind Method
  • Research Design
  • Public Health
  • Psychometrics
  • Prospective Studies
  • Neuropsychological Tests
  • Models, Psychological
  • Middle Aged