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Hippocampal remodeling and damage by corticosteroids: implications for mood disorders.

Publication ,  Journal Article
Brown, ES; Rush, AJ; McEwen, BS
Published in: Neuropsychopharmacology
October 1999

Mood disorders are common, recurrent and disabling illnesses which are frequently associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation and memory loss. The hippocampus provides negative feedback to the HPA axis and has an important role in key aspects of spatial and declarative memory. Thus, hippocampal dysfunction could account for both the memory impairment and neuroendocrine abnormalities found in mood disorders. The critical role of the hippocampus in declarative memory, emotional processing, and vulnerability to stress has been demonstrated in both animal and human studies. Cellular processes in the hippocampus including long-term potentiation, neurogenesis, and dendritic remodeling are currently areas of intense study. Human studies report cognitive impairment consistent with hippocampal dysfunction in depression, bipolar disorder, Cushing's disease, and in those individuals receiving exogenous corticosteroids. This review examines data on the role of corticosteroids in hippocampal remodeling and atrophy in patients with mood disorders. Interventions to prevent or reverse the damaging effects of corticosteroids on the hippocampus are discussed.

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Published In

Neuropsychopharmacology

DOI

ISSN

0893-133X

Publication Date

October 1999

Volume

21

Issue

4

Start / End Page

474 / 484

Location

England

Related Subject Headings

  • Psychiatry
  • Pituitary-Adrenal System
  • Mood Disorders
  • Humans
  • Hippocampus
  • Cushing Syndrome
  • Cognition Disorders
  • Cognition
  • Brain
  • Adrenal Cortex Hormones
 

Citation

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Brown, E. S., Rush, A. J., & McEwen, B. S. (1999). Hippocampal remodeling and damage by corticosteroids: implications for mood disorders. Neuropsychopharmacology, 21(4), 474–484. https://doi.org/10.1016/S0893-133X(99)00054-8
Brown, E. S., A. J. Rush, and B. S. McEwen. “Hippocampal remodeling and damage by corticosteroids: implications for mood disorders.Neuropsychopharmacology 21, no. 4 (October 1999): 474–84. https://doi.org/10.1016/S0893-133X(99)00054-8.
Brown ES, Rush AJ, McEwen BS. Hippocampal remodeling and damage by corticosteroids: implications for mood disorders. Neuropsychopharmacology. 1999 Oct;21(4):474–84.
Brown, E. S., et al. “Hippocampal remodeling and damage by corticosteroids: implications for mood disorders.Neuropsychopharmacology, vol. 21, no. 4, Oct. 1999, pp. 474–84. Pubmed, doi:10.1016/S0893-133X(99)00054-8.
Brown ES, Rush AJ, McEwen BS. Hippocampal remodeling and damage by corticosteroids: implications for mood disorders. Neuropsychopharmacology. 1999 Oct;21(4):474–484.
Journal cover image

Published In

Neuropsychopharmacology

DOI

ISSN

0893-133X

Publication Date

October 1999

Volume

21

Issue

4

Start / End Page

474 / 484

Location

England

Related Subject Headings

  • Psychiatry
  • Pituitary-Adrenal System
  • Mood Disorders
  • Humans
  • Hippocampus
  • Cushing Syndrome
  • Cognition Disorders
  • Cognition
  • Brain
  • Adrenal Cortex Hormones