Skip to main content

Neurobiological antecedents of multisite pain in children.

Publication ,  Journal Article
Kaplan, CM; Schrepf, A; Mawla, I; Ichesco, E; Boehnke, KF; Beltz, A; Foxen-Craft, E; Puglia, MP; Tsodikov, A; Williams, DA; Hassett, AL ...
Published in: Pain
April 2022

Altered brain structure and function is evident in adults with multisite chronic pain. Although many such adults trace their pain back to childhood, it has been difficult to disentangle whether central nervous system alterations precede or are consequences of chronic pain. If the former is true, aberrant brain activity may identify children vulnerable to developing chronic pain later in life. We examined structural and functional brain magnetic resonance imaging metrics in a subset of children from the first 2 assessments of the Adolescent Brain and Cognitive Development Study. Children (aged 9-10) who were pain free at baseline and then developed multisite pain 1 year later (n = 115) were matched to control children who were pain free at both timepoints (n = 230). We analyzed brain structure (cortical thickness and gray matter volume) and function (spontaneous neural activity and functional connectivity). Results were deemed significant at the cluster level P < 0.05 false discovery rate corrected for multiple comparisons. At baseline, children who subsequently developed multisite pain had increased neural activity in superior parietal /primary somatosensory and motor cortices and decreased activity in the medial prefrontal cortex. They also exhibited stronger functional connectivity between the salience network, somatosensory, and default mode network regions. No significant differences in the brain structure were observed. Increased neural activity and functional connectivity between brain regions, consistent to that seen in adults with chronic pain, exist in children before developing multisite pain. These findings may represent a neural vulnerability to developing future chronic pain.

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Pain

DOI

EISSN

1872-6623

ISSN

0304-3959

Publication Date

April 2022

Volume

163

Issue

4

Start / End Page

e596 / e603

Related Subject Headings

  • Neural Pathways
  • Magnetic Resonance Imaging
  • Humans
  • Chronic Pain
  • Child
  • Brain Mapping
  • Brain
  • Anesthesiology
  • Adult
  • Adolescent
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kaplan, C. M., Schrepf, A., Mawla, I., Ichesco, E., Boehnke, K. F., Beltz, A., … Harris, R. E. (2022). Neurobiological antecedents of multisite pain in children. Pain, 163(4), e596–e603. https://doi.org/10.1097/j.pain.0000000000002431
Kaplan, Chelsea M., Andrew Schrepf, Ishtiaq Mawla, Eric Ichesco, Kevin F. Boehnke, Adriene Beltz, Emily Foxen-Craft, et al. “Neurobiological antecedents of multisite pain in children.Pain 163, no. 4 (April 2022): e596–603. https://doi.org/10.1097/j.pain.0000000000002431.
Kaplan CM, Schrepf A, Mawla I, Ichesco E, Boehnke KF, Beltz A, et al. Neurobiological antecedents of multisite pain in children. Pain. 2022 Apr;163(4):e596–603.
Kaplan, Chelsea M., et al. “Neurobiological antecedents of multisite pain in children.Pain, vol. 163, no. 4, Apr. 2022, pp. e596–603. Epmc, doi:10.1097/j.pain.0000000000002431.
Kaplan CM, Schrepf A, Mawla I, Ichesco E, Boehnke KF, Beltz A, Foxen-Craft E, Puglia MP, Tsodikov A, Williams DA, Hassett AL, Clauw DJ, Harte SE, Harris RE. Neurobiological antecedents of multisite pain in children. Pain. 2022 Apr;163(4):e596–e603.

Published In

Pain

DOI

EISSN

1872-6623

ISSN

0304-3959

Publication Date

April 2022

Volume

163

Issue

4

Start / End Page

e596 / e603

Related Subject Headings

  • Neural Pathways
  • Magnetic Resonance Imaging
  • Humans
  • Chronic Pain
  • Child
  • Brain Mapping
  • Brain
  • Anesthesiology
  • Adult
  • Adolescent