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Long Noncoding RNAs in Atherosclerosis and Vascular Injury: Pathobiology, Biomarkers, and Targets for Therapy.

Publication ,  Journal Article
Pierce, JB; Feinberg, MW
Published in: Arteriosclerosis, thrombosis, and vascular biology
September 2020

Despite major advances in the primary and secondary prevention of atherosclerosis and its risk factors, atherosclerotic cardiovascular disease remains a major clinical and financial burden on individuals and health systems worldwide. In addition, neointima formation and proliferation due to mechanical trauma to the vessel wall during percutaneous coronary interventions can lead to vascular restenosis and limit the longevity and effectiveness of coronary revascularization. Long noncoding RNAs (lncRNAs) have emerged as a novel class of epigenetic regulators with critical roles in the pathogenesis of atherosclerosis and restenosis following vascular injury. Here, we provide an in-depth review of lncRNAs that regulate the development of atherosclerosis or contribute to the pathogenesis of restenosis following mechanical vascular injury. We describe the diverse array of intracellular mechanisms by which lncRNAs exert their regulatory effects. We highlight the utility and challenges of lncRNAs as biomarkers. Finally, we discuss the immense translational potential of lncRNAs and strategies for targeting them therapeutically using oligonucleotide-based therapeutics and novel gene therapy platforms.

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Published In

Arteriosclerosis, thrombosis, and vascular biology

DOI

EISSN

1524-4636

ISSN

1079-5642

Publication Date

September 2020

Volume

40

Issue

9

Start / End Page

2002 / 2017

Related Subject Headings

  • Vascular System Injuries
  • Vascular Remodeling
  • Signal Transduction
  • RNAi Therapeutics
  • RNA, Long Noncoding
  • Plaque, Atherosclerotic
  • Oligonucleotides, Antisense
  • Humans
  • Genetic Markers
  • Epigenesis, Genetic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Pierce, J. B., & Feinberg, M. W. (2020). Long Noncoding RNAs in Atherosclerosis and Vascular Injury: Pathobiology, Biomarkers, and Targets for Therapy. Arteriosclerosis, Thrombosis, and Vascular Biology, 40(9), 2002–2017. https://doi.org/10.1161/atvbaha.120.314222
Pierce, Jacob B., and Mark W. Feinberg. “Long Noncoding RNAs in Atherosclerosis and Vascular Injury: Pathobiology, Biomarkers, and Targets for Therapy.Arteriosclerosis, Thrombosis, and Vascular Biology 40, no. 9 (September 2020): 2002–17. https://doi.org/10.1161/atvbaha.120.314222.
Pierce JB, Feinberg MW. Long Noncoding RNAs in Atherosclerosis and Vascular Injury: Pathobiology, Biomarkers, and Targets for Therapy. Arteriosclerosis, thrombosis, and vascular biology. 2020 Sep;40(9):2002–17.
Pierce, Jacob B., and Mark W. Feinberg. “Long Noncoding RNAs in Atherosclerosis and Vascular Injury: Pathobiology, Biomarkers, and Targets for Therapy.Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 40, no. 9, Sept. 2020, pp. 2002–17. Epmc, doi:10.1161/atvbaha.120.314222.
Pierce JB, Feinberg MW. Long Noncoding RNAs in Atherosclerosis and Vascular Injury: Pathobiology, Biomarkers, and Targets for Therapy. Arteriosclerosis, thrombosis, and vascular biology. 2020 Sep;40(9):2002–2017.

Published In

Arteriosclerosis, thrombosis, and vascular biology

DOI

EISSN

1524-4636

ISSN

1079-5642

Publication Date

September 2020

Volume

40

Issue

9

Start / End Page

2002 / 2017

Related Subject Headings

  • Vascular System Injuries
  • Vascular Remodeling
  • Signal Transduction
  • RNAi Therapeutics
  • RNA, Long Noncoding
  • Plaque, Atherosclerotic
  • Oligonucleotides, Antisense
  • Humans
  • Genetic Markers
  • Epigenesis, Genetic