Pyrrolidine-Oxadiazolone Conjugates as Organocatalysts in Asymmetric Michael Reaction.
Publication
, Journal Article
Mahato, CK; Mukherjee, S; Kundu, M; Pramanik, A
Published in: The Journal of Organic Chemistry
January 2019
Pyrrolidine-oxadiazolone based organocatalysts are envisaged, synthesized, and utilized for asymmetric Michael reactions. Results of the investigations suggest that some of the catalysts are indeed efficient for stereoselective 1,4-conjugated Michael additions (dr: >97:3, ee up to 99%) in high chemical yields (up to 97%) often in short reaction time. As an extension, one enantiopure Michael adduct has been utilized to synthesize optically active octahydroindole.
Duke Scholars
Published In
The Journal of Organic Chemistry
DOI
EISSN
1520-6904
ISSN
0022-3263
Publication Date
January 2019
Volume
84
Issue
2
Start / End Page
1053 / 1063
Related Subject Headings
- Organic Chemistry
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Mahato, C. K., Mukherjee, S., Kundu, M., & Pramanik, A. (2019). Pyrrolidine-Oxadiazolone Conjugates as Organocatalysts in Asymmetric Michael Reaction. The Journal of Organic Chemistry, 84(2), 1053–1063. https://doi.org/10.1021/acs.joc.8b02393
Mahato, Chandan K., Sayan Mukherjee, Mrinalkanti Kundu, and Animesh Pramanik. “Pyrrolidine-Oxadiazolone Conjugates as Organocatalysts in Asymmetric Michael Reaction.” The Journal of Organic Chemistry 84, no. 2 (January 2019): 1053–63. https://doi.org/10.1021/acs.joc.8b02393.
Mahato CK, Mukherjee S, Kundu M, Pramanik A. Pyrrolidine-Oxadiazolone Conjugates as Organocatalysts in Asymmetric Michael Reaction. The Journal of Organic Chemistry. 2019 Jan;84(2):1053–63.
Mahato, Chandan K., et al. “Pyrrolidine-Oxadiazolone Conjugates as Organocatalysts in Asymmetric Michael Reaction.” The Journal of Organic Chemistry, vol. 84, no. 2, Jan. 2019, pp. 1053–63. Epmc, doi:10.1021/acs.joc.8b02393.
Mahato CK, Mukherjee S, Kundu M, Pramanik A. Pyrrolidine-Oxadiazolone Conjugates as Organocatalysts in Asymmetric Michael Reaction. The Journal of Organic Chemistry. 2019 Jan;84(2):1053–1063.
Published In
The Journal of Organic Chemistry
DOI
EISSN
1520-6904
ISSN
0022-3263
Publication Date
January 2019
Volume
84
Issue
2
Start / End Page
1053 / 1063
Related Subject Headings
- Organic Chemistry
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry