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Iterative in situ click chemistry creates antibody-like protein-capture agents.

Publication ,  Journal Article
Agnew, HD; Rohde, RD; Millward, SW; Nag, A; Yeo, W-S; Hein, JE; Pitram, SM; Tariq, AA; Burns, VM; Krom, RJ; Fokin, VV; Sharpless, KB; Heath, JR
Published in: Angew Chem Int Ed Engl
2009

Special agents for protein capture: Iterative in situ click chemistry (see scheme for the tertiary ligand screen) and the one-bead-one-compound method for the creation of a peptide library enable the fragment-based assembly of selective high-affinity protein-capture agents. The resulting ligands are water-soluble and stable chemically, biochemically, and thermally. They can be produced in gram quantities through copper(I)-catalyzed cycloaddition.

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Published In

Angew Chem Int Ed Engl

DOI

EISSN

1521-3773

Publication Date

2009

Volume

48

Issue

27

Start / End Page

4944 / 4948

Location

Germany

Related Subject Headings

  • Triazoles
  • Proteins
  • Protein Binding
  • Peptides
  • Peptide Library
  • Organic Chemistry
  • Ligands
  • Copper
  • Catalysis
  • Antibodies
 

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Agnew, H. D., Rohde, R. D., Millward, S. W., Nag, A., Yeo, W.-S., Hein, J. E., … Heath, J. R. (2009). Iterative in situ click chemistry creates antibody-like protein-capture agents. Angew Chem Int Ed Engl, 48(27), 4944–4948. https://doi.org/10.1002/anie.200900488
Agnew, Heather D., Rosemary D. Rohde, Steven W. Millward, Arundhati Nag, Woon-Seok Yeo, Jason E. Hein, Suresh M. Pitram, et al. “Iterative in situ click chemistry creates antibody-like protein-capture agents.Angew Chem Int Ed Engl 48, no. 27 (2009): 4944–48. https://doi.org/10.1002/anie.200900488.
Agnew HD, Rohde RD, Millward SW, Nag A, Yeo W-S, Hein JE, et al. Iterative in situ click chemistry creates antibody-like protein-capture agents. Angew Chem Int Ed Engl. 2009;48(27):4944–8.
Agnew, Heather D., et al. “Iterative in situ click chemistry creates antibody-like protein-capture agents.Angew Chem Int Ed Engl, vol. 48, no. 27, 2009, pp. 4944–48. Pubmed, doi:10.1002/anie.200900488.
Agnew HD, Rohde RD, Millward SW, Nag A, Yeo W-S, Hein JE, Pitram SM, Tariq AA, Burns VM, Krom RJ, Fokin VV, Sharpless KB, Heath JR. Iterative in situ click chemistry creates antibody-like protein-capture agents. Angew Chem Int Ed Engl. 2009;48(27):4944–4948.
Journal cover image

Published In

Angew Chem Int Ed Engl

DOI

EISSN

1521-3773

Publication Date

2009

Volume

48

Issue

27

Start / End Page

4944 / 4948

Location

Germany

Related Subject Headings

  • Triazoles
  • Proteins
  • Protein Binding
  • Peptides
  • Peptide Library
  • Organic Chemistry
  • Ligands
  • Copper
  • Catalysis
  • Antibodies