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Selective Autophagy of BES1 Mediated by DSK2 Balances Plant Growth and Survival.

Publication ,  Journal Article
Nolan, TM; Brennan, B; Yang, M; Chen, J; Zhang, M; Li, Z; Wang, X; Bassham, DC; Walley, J; Yin, Y
Published in: Developmental cell
April 2017

Plants encounter a variety of stresses and must fine-tune their growth and stress-response programs to best suit their environment. BES1 functions as a master regulator in the brassinosteroid (BR) pathway that promotes plant growth. Here, we show that BES1 interacts with the ubiquitin receptor protein DSK2 and is targeted to the autophagy pathway during stress via the interaction of DSK2 with ATG8, a ubiquitin-like protein directing autophagosome formation and cargo recruitment. Additionally, DSK2 is phosphorylated by the GSK3-like kinase BIN2, a negative regulator in the BR pathway. BIN2 phosphorylation of DSK2 flanking its ATG8 interacting motifs (AIMs) promotes DSK2-ATG8 interaction, thereby targeting BES1 for degradation. Accordingly, loss-of-function dsk2 mutants accumulate BES1, have altered global gene expression profiles, and have compromised stress responses. Our results thus reveal that plants coordinate growth and stress responses by integrating BR and autophagy pathways and identify the molecular basis of this crosstalk.

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Published In

Developmental cell

DOI

EISSN

1878-1551

ISSN

1534-5807

Publication Date

April 2017

Volume

41

Issue

1

Start / End Page

33 / 46.e7

Related Subject Headings

  • Ubiquitin-Protein Ligases
  • Ubiquitin
  • Stress, Physiological
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Cell Surface
  • Proteolysis
  • Protein Binding
  • Proteasome Endopeptidase Complex
  • Plant Development
  • Phosphorylation
 

Citation

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Nolan, T. M., Brennan, B., Yang, M., Chen, J., Zhang, M., Li, Z., … Yin, Y. (2017). Selective Autophagy of BES1 Mediated by DSK2 Balances Plant Growth and Survival. Developmental Cell, 41(1), 33-46.e7. https://doi.org/10.1016/j.devcel.2017.03.013
Nolan, Trevor M., Benjamin Brennan, Mengran Yang, Jiani Chen, Mingcai Zhang, Zhaohu Li, Xuelu Wang, Diane C. Bassham, Justin Walley, and Yanhai Yin. “Selective Autophagy of BES1 Mediated by DSK2 Balances Plant Growth and Survival.Developmental Cell 41, no. 1 (April 2017): 33-46.e7. https://doi.org/10.1016/j.devcel.2017.03.013.
Nolan TM, Brennan B, Yang M, Chen J, Zhang M, Li Z, et al. Selective Autophagy of BES1 Mediated by DSK2 Balances Plant Growth and Survival. Developmental cell. 2017 Apr;41(1):33-46.e7.
Nolan, Trevor M., et al. “Selective Autophagy of BES1 Mediated by DSK2 Balances Plant Growth and Survival.Developmental Cell, vol. 41, no. 1, Apr. 2017, pp. 33-46.e7. Epmc, doi:10.1016/j.devcel.2017.03.013.
Nolan TM, Brennan B, Yang M, Chen J, Zhang M, Li Z, Wang X, Bassham DC, Walley J, Yin Y. Selective Autophagy of BES1 Mediated by DSK2 Balances Plant Growth and Survival. Developmental cell. 2017 Apr;41(1):33-46.e7.
Journal cover image

Published In

Developmental cell

DOI

EISSN

1878-1551

ISSN

1534-5807

Publication Date

April 2017

Volume

41

Issue

1

Start / End Page

33 / 46.e7

Related Subject Headings

  • Ubiquitin-Protein Ligases
  • Ubiquitin
  • Stress, Physiological
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Cell Surface
  • Proteolysis
  • Protein Binding
  • Proteasome Endopeptidase Complex
  • Plant Development
  • Phosphorylation