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The AP2/ERF Transcription Factor TINY Modulates Brassinosteroid-Regulated Plant Growth and Drought Responses in Arabidopsis.

Publication ,  Journal Article
Xie, Z; Nolan, T; Jiang, H; Tang, B; Zhang, M; Li, Z; Yin, Y
Published in: The Plant Cell
August 2019

APETALA2/ETHYLENE RESPONSIVE FACTOR (AP2/ERF) family transcription factors have well-documented functions in stress responses, but their roles in brassinosteroid (BR)-regulated growth and stress responses have not been established. Here, we show that the Arabidopsis (Arabidopsis thaliana) stress-inducible AP2/ERF transcription factor TINY inhibits BR-regulated growth while promoting drought responses. TINY-overexpressing plants have stunted growth, increased sensitivity to BR biosynthesis inhibitors, and compromised BR-responsive gene expression. By contrast, tiny tiny2 tiny3 triple mutants have increased BR-regulated growth and BR-responsive gene expression. TINY positively regulates drought responses by activating drought-responsive genes and promoting abscisic acid-mediated stomatal closure. Global gene expression studies revealed that TINY and BRs have opposite effects on plant growth and stress response genes. TINY interacts with and antagonizes BRASSINOSTERIOID INSENSITIVE1-ETHYL METHANESULFONATE SUPRESSOR1 (BES1) in the regulation of these genes. Glycogen synthase kinase 3-like protein kinase BR-INSENSITIVE2 (BIN2), a negative regulator in the BR pathway, phosphorylates and stabilizes TINY, providing a mechanism for BR-mediated downregulation of TINY to prevent activation of stress responses under optimal growth conditions. Taken together, our results demonstrate that BR signaling negatively regulates TINY through BIN2 phosphorylation and TINY positively regulates drought responses, as well as inhibiting BR-mediated growth through TINY-BES1 antagonistic interactions. Our results thus provide insight into the coordination of BR-regulated growth and drought responses.

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Published In

The Plant Cell

DOI

EISSN

1532-298X

ISSN

1040-4651

Publication Date

August 2019

Volume

31

Issue

8

Start / End Page

1788 / 1806

Related Subject Headings

  • Signal Transduction
  • Protein Kinases
  • Plants, Genetically Modified
  • Plant Biology & Botany
  • Homeodomain Proteins
  • Gene Expression Regulation, Plant
  • Droughts
  • DNA-Binding Proteins
  • Arabidopsis Proteins
  • Arabidopsis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Xie, Z., Nolan, T., Jiang, H., Tang, B., Zhang, M., Li, Z., & Yin, Y. (2019). The AP2/ERF Transcription Factor TINY Modulates Brassinosteroid-Regulated Plant Growth and Drought Responses in Arabidopsis. The Plant Cell, 31(8), 1788–1806. https://doi.org/10.1105/tpc.18.00918
Xie, Zhouli, Trevor Nolan, Hao Jiang, Buyun Tang, Mingcai Zhang, Zhaohu Li, and Yanhai Yin. “The AP2/ERF Transcription Factor TINY Modulates Brassinosteroid-Regulated Plant Growth and Drought Responses in Arabidopsis.The Plant Cell 31, no. 8 (August 2019): 1788–1806. https://doi.org/10.1105/tpc.18.00918.
Xie Z, Nolan T, Jiang H, Tang B, Zhang M, Li Z, et al. The AP2/ERF Transcription Factor TINY Modulates Brassinosteroid-Regulated Plant Growth and Drought Responses in Arabidopsis. The Plant Cell. 2019 Aug;31(8):1788–806.
Xie, Zhouli, et al. “The AP2/ERF Transcription Factor TINY Modulates Brassinosteroid-Regulated Plant Growth and Drought Responses in Arabidopsis.The Plant Cell, vol. 31, no. 8, Aug. 2019, pp. 1788–806. Epmc, doi:10.1105/tpc.18.00918.
Xie Z, Nolan T, Jiang H, Tang B, Zhang M, Li Z, Yin Y. The AP2/ERF Transcription Factor TINY Modulates Brassinosteroid-Regulated Plant Growth and Drought Responses in Arabidopsis. The Plant Cell. 2019 Aug;31(8):1788–1806.

Published In

The Plant Cell

DOI

EISSN

1532-298X

ISSN

1040-4651

Publication Date

August 2019

Volume

31

Issue

8

Start / End Page

1788 / 1806

Related Subject Headings

  • Signal Transduction
  • Protein Kinases
  • Plants, Genetically Modified
  • Plant Biology & Botany
  • Homeodomain Proteins
  • Gene Expression Regulation, Plant
  • Droughts
  • DNA-Binding Proteins
  • Arabidopsis Proteins
  • Arabidopsis