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Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies.

Publication ,  Journal Article
Dodge, MJ; MacNeil, KM; Tessier, TM; Weinberg, JB; Mymryk, JS
Published in: Antiviral Res
April 2021

Human adenoviruses (HAdV) are ubiquitous human pathogens that cause a significant burden of respiratory, ocular, and gastrointestinal illnesses. Although HAdV infections are generally self-limiting, pediatric and immunocompromised individuals are at particular risk for developing severe disease. Currently, no approved antiviral therapies specific to HAdV exist. Recent outbreaks underscore the need for effective antiviral agents to treat life-threatening infections. In this review we will focus on recent developments in search of potential therapeutic agents for controlling HAdV infections, with a focus on those targeting post-entry stages of the virus replicative cycle.

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Published In

Antiviral Res

DOI

EISSN

1872-9096

Publication Date

April 2021

Volume

188

Start / End Page

105034

Location

Netherlands

Related Subject Headings

  • Virus Replication
  • Virology
  • T-Lymphocytes
  • Immunotherapy, Adoptive
  • Humans
  • Gene Expression
  • Epigenesis, Genetic
  • Drug Therapy, Combination
  • Drug Repositioning
  • DNA Replication
 

Citation

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Dodge, M. J., MacNeil, K. M., Tessier, T. M., Weinberg, J. B., & Mymryk, J. S. (2021). Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies. Antiviral Res, 188, 105034. https://doi.org/10.1016/j.antiviral.2021.105034
Dodge, Mackenzie J., Katelyn M. MacNeil, Tanner M. Tessier, Jason B. Weinberg, and Joe S. Mymryk. “Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies.Antiviral Res 188 (April 2021): 105034. https://doi.org/10.1016/j.antiviral.2021.105034.
Dodge MJ, MacNeil KM, Tessier TM, Weinberg JB, Mymryk JS. Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies. Antiviral Res. 2021 Apr;188:105034.
Dodge, Mackenzie J., et al. “Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies.Antiviral Res, vol. 188, Apr. 2021, p. 105034. Pubmed, doi:10.1016/j.antiviral.2021.105034.
Dodge MJ, MacNeil KM, Tessier TM, Weinberg JB, Mymryk JS. Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies. Antiviral Res. 2021 Apr;188:105034.
Journal cover image

Published In

Antiviral Res

DOI

EISSN

1872-9096

Publication Date

April 2021

Volume

188

Start / End Page

105034

Location

Netherlands

Related Subject Headings

  • Virus Replication
  • Virology
  • T-Lymphocytes
  • Immunotherapy, Adoptive
  • Humans
  • Gene Expression
  • Epigenesis, Genetic
  • Drug Therapy, Combination
  • Drug Repositioning
  • DNA Replication