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Fertility treatment is associated with multiple meningiomas and younger age at diagnosis.

Publication ,  Journal Article
Shahin, MN; Magill, ST; Dalle Ore, CL; Viner, JA; Peters, PN; Solomon, DA; McDermott, MW
Published in: Journal of neuro-oncology
May 2019

Meningiomas are more common in females and 70-80% express the progesterone receptor, raising the possibility that high-dose exogenous estrogen/progesterone exposure, such as occurs during fertility treatments, may increase the risk of developing a meningioma. The goal of this study was to report the incidence of prior fertility treatment in a consecutive series of female meningioma patients.A retrospective review (2015-2018) was performed of female patients with meningioma, and those with prior fertility treatment were compared to those without fertility treatment using standard statistical methods.Of 206 female patients with meningioma, 26 (12.6%) had a history of fertility treatments. Patients underwent various forms of assisted reproductive technology including: in vitro fertilization (50.0%), clomiphene with or without intrauterine insemination (34.6%), and unspecified (19.2%). Median follow up was 1.8 years. Tumors were WHO grade I (78.6%) or grade II (21.4%). Patients who underwent fertility treatments presented at significantly younger mean age compared to those who had not (51.8 vs. 57.3 years, p = 0.0135, 2-tailed T-test), and on multivariate analysis were more likely to have multiple meningiomas (OR 4.97, 95% CI 1.4-18.1, p = 0.0154) and convexity/falx meningiomas (OR 4.45, 95% CI 1.7-11.5, p = 0.0021).Patients in this cohort with a history of fertility treatment were more likely to present at a younger age and have multiple and convexity/falx meningiomas, emphasizing the importance of taking estrogen/progesterone exposure history when evaluating patients with meningioma. Future clinical studies at other centers in larger populations and laboratory investigations are needed to determine the role of fertility treatment in meningioma development.

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Published In

Journal of neuro-oncology

DOI

EISSN

1573-7373

ISSN

0167-594X

Publication Date

May 2019

Volume

143

Issue

1

Start / End Page

137 / 144

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Reproductive Techniques, Assisted
  • Receptors, Progesterone
  • Receptors, Estrogen
  • Oncology & Carcinogenesis
  • Neoplasm Grading
  • Middle Aged
  • Meningioma
  • Meningeal Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
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Shahin, M. N., Magill, S. T., Dalle Ore, C. L., Viner, J. A., Peters, P. N., Solomon, D. A., & McDermott, M. W. (2019). Fertility treatment is associated with multiple meningiomas and younger age at diagnosis. Journal of Neuro-Oncology, 143(1), 137–144. https://doi.org/10.1007/s11060-019-03147-6
Shahin, Maryam N., Stephen T. Magill, Cecilia L. Dalle Ore, Jennifer A. Viner, Pamela N. Peters, David A. Solomon, and Michael W. McDermott. “Fertility treatment is associated with multiple meningiomas and younger age at diagnosis.Journal of Neuro-Oncology 143, no. 1 (May 2019): 137–44. https://doi.org/10.1007/s11060-019-03147-6.
Shahin MN, Magill ST, Dalle Ore CL, Viner JA, Peters PN, Solomon DA, et al. Fertility treatment is associated with multiple meningiomas and younger age at diagnosis. Journal of neuro-oncology. 2019 May;143(1):137–44.
Shahin, Maryam N., et al. “Fertility treatment is associated with multiple meningiomas and younger age at diagnosis.Journal of Neuro-Oncology, vol. 143, no. 1, May 2019, pp. 137–44. Epmc, doi:10.1007/s11060-019-03147-6.
Shahin MN, Magill ST, Dalle Ore CL, Viner JA, Peters PN, Solomon DA, McDermott MW. Fertility treatment is associated with multiple meningiomas and younger age at diagnosis. Journal of neuro-oncology. 2019 May;143(1):137–144.
Journal cover image

Published In

Journal of neuro-oncology

DOI

EISSN

1573-7373

ISSN

0167-594X

Publication Date

May 2019

Volume

143

Issue

1

Start / End Page

137 / 144

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Reproductive Techniques, Assisted
  • Receptors, Progesterone
  • Receptors, Estrogen
  • Oncology & Carcinogenesis
  • Neoplasm Grading
  • Middle Aged
  • Meningioma
  • Meningeal Neoplasms