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PD-L1 Expression Correlates With Young Age and CD8+ TIL Density in Poorly Differentiated Cervical Squamous Cell Carcinoma.

Publication ,  Journal Article
Saglam, O; Zhou, J; Wang, X; Conejo-Garcia, JR
Published in: Int J Gynecol Pathol
September 2020

Management options are limited in advanced or recurrent cervical carcinoma. The Food and Drug Administration has recently approved programed cell death-1 (PD-1)/PD-ligand-1 (PD-L1) inhibitors for the treatment of advanced PD-L1 positive cervical cancer. We studied PD-L1 expression in cervical squamous cell carcinoma (CSCC) samples initially on a The tissue microarray and then in full-tissue sections from poorly differentiated (grade 3) cancers. Tissue microarray was composed of 45 grade 3 and 2 (moderately differentiated) tumors. PD-L1 expression was evaluated as categorical data and by obtaining combined positive score of neoplastic and mononuclear inflammatory cells. In tissue microarray samples PD-L1 expression was higher in poorly differentiated cancers compared with grade 2 tumors by immunohistochemistry. Full-tissue sections from grade 3 CSCC (n=22) were stained with PD-L1, CD8, and VEGF antibodies. Poorly differentiated CSCC samples had diffuse (≥50%) and focal/patchy staining patterns. The latter pattern showed localized tumor-stroma interface staining in 5 samples with low combined positive score. Importantly, younger patients (median=36) had tumors with higher expression. PD-L1 expression was associated with larger tumor size and absent lymphovascular invasion. In addition, CD8 tumor-infiltrating lymphocyte density within the neoplastic tissue matched with PD-L1 levels. The overall survival rates did not correlate with PD-L1 expression. However, in early-stage disease high CD8 tumor-infiltrating lymphocyte density within the peritumoral stroma was associated with better survival outcomes in multivariate analysis. PD-L1 expression and CD8 tumor-infiltrating lymphocyte density may be useful to define a subgroup of patients with relatively better prognosis in poorly differentiated CSCC. It is warranted to validate our results in a larger sample size.

Duke Scholars

Published In

Int J Gynecol Pathol

DOI

EISSN

1538-7151

Publication Date

September 2020

Volume

39

Issue

5

Start / End Page

428 / 435

Location

United States

Related Subject Headings

  • Young Adult
  • Vascular Endothelial Growth Factor A
  • Uterine Cervical Neoplasms
  • Tissue Array Analysis
  • Survival Rate
  • Prognosis
  • Pathology
  • Middle Aged
  • Lymphocytes, Tumor-Infiltrating
  • Immunohistochemistry
 

Citation

APA
Chicago
ICMJE
MLA
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Saglam, O., Zhou, J., Wang, X., & Conejo-Garcia, J. R. (2020). PD-L1 Expression Correlates With Young Age and CD8+ TIL Density in Poorly Differentiated Cervical Squamous Cell Carcinoma. Int J Gynecol Pathol, 39(5), 428–435. https://doi.org/10.1097/PGP.0000000000000623
Saglam, Ozlen, Junmin Zhou, Xuefeng Wang, and Jose R. Conejo-Garcia. “PD-L1 Expression Correlates With Young Age and CD8+ TIL Density in Poorly Differentiated Cervical Squamous Cell Carcinoma.Int J Gynecol Pathol 39, no. 5 (September 2020): 428–35. https://doi.org/10.1097/PGP.0000000000000623.
Saglam O, Zhou J, Wang X, Conejo-Garcia JR. PD-L1 Expression Correlates With Young Age and CD8+ TIL Density in Poorly Differentiated Cervical Squamous Cell Carcinoma. Int J Gynecol Pathol. 2020 Sep;39(5):428–35.
Saglam, Ozlen, et al. “PD-L1 Expression Correlates With Young Age and CD8+ TIL Density in Poorly Differentiated Cervical Squamous Cell Carcinoma.Int J Gynecol Pathol, vol. 39, no. 5, Sept. 2020, pp. 428–35. Pubmed, doi:10.1097/PGP.0000000000000623.
Saglam O, Zhou J, Wang X, Conejo-Garcia JR. PD-L1 Expression Correlates With Young Age and CD8+ TIL Density in Poorly Differentiated Cervical Squamous Cell Carcinoma. Int J Gynecol Pathol. 2020 Sep;39(5):428–435.

Published In

Int J Gynecol Pathol

DOI

EISSN

1538-7151

Publication Date

September 2020

Volume

39

Issue

5

Start / End Page

428 / 435

Location

United States

Related Subject Headings

  • Young Adult
  • Vascular Endothelial Growth Factor A
  • Uterine Cervical Neoplasms
  • Tissue Array Analysis
  • Survival Rate
  • Prognosis
  • Pathology
  • Middle Aged
  • Lymphocytes, Tumor-Infiltrating
  • Immunohistochemistry