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Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells.

Publication ,  Journal Article
Conejo-Garcia, JR; Benencia, F; Courreges, MC; Khang, E; Zhang, L; Mohamed-Hadley, A; Vinocur, JM; Buckanovich, RJ; Thompson, CB; Levine, B; Coukos, G
Published in: Cancer Biol Ther
2003

NKG2D serves as one of the most potent activating receptors for effector lymphocytes. in peripheral tissues. Here we report the characterization of Letal, the first human trans-membrane NKG2D ligand lacking an immunoglobulin-like alpha-3 ectodomain. Letal is constitutively expressed by a variety of normal tissues, and is upregulated in tumor cells of different origins. Unlike other NKG2D ligands, Letal mRNA expression progressively decreased after treatment of tumor cells with retinoic acid. Simultaneous T-cell receptor activation and engagement of Letal stimulated proliferation of CD8(+) cells and dramatically increased IL-2 and IFNgamma secretion. In addition, Letal induced the killing of cancer cells by CD8(+) and NK cells. These results suggest that Letal delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes.

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Published In

Cancer Biol Ther

DOI

ISSN

1538-4047

Publication Date

2003

Volume

2

Issue

4

Start / End Page

446 / 451

Location

United States

Related Subject Headings

  • Type C Phospholipases
  • Tretinoin
  • Sequence Homology, Amino Acid
  • Receptors, Natural Killer Cell
  • Receptors, Immunologic
  • Receptors, Antigen, T-Cell
  • RNA, Messenger
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • NK Cell Lectin-Like Receptor Subfamily K
 

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Conejo-Garcia, J. R., Benencia, F., Courreges, M. C., Khang, E., Zhang, L., Mohamed-Hadley, A., … Coukos, G. (2003). Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells. Cancer Biol Ther, 2(4), 446–451. https://doi.org/10.4161/cbt.2.4.479
Conejo-Garcia, Jose R., Fabian Benencia, Maria C. Courreges, Eugene Khang, Lin Zhang, Alisha Mohamed-Hadley, Jeffrey M. Vinocur, et al. “Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells.Cancer Biol Ther 2, no. 4 (2003): 446–51. https://doi.org/10.4161/cbt.2.4.479.
Conejo-Garcia JR, Benencia F, Courreges MC, Khang E, Zhang L, Mohamed-Hadley A, et al. Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells. Cancer Biol Ther. 2003;2(4):446–51.
Conejo-Garcia, Jose R., et al. “Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells.Cancer Biol Ther, vol. 2, no. 4, 2003, pp. 446–51. Pubmed, doi:10.4161/cbt.2.4.479.
Conejo-Garcia JR, Benencia F, Courreges MC, Khang E, Zhang L, Mohamed-Hadley A, Vinocur JM, Buckanovich RJ, Thompson CB, Levine B, Coukos G. Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells. Cancer Biol Ther. 2003;2(4):446–451.

Published In

Cancer Biol Ther

DOI

ISSN

1538-4047

Publication Date

2003

Volume

2

Issue

4

Start / End Page

446 / 451

Location

United States

Related Subject Headings

  • Type C Phospholipases
  • Tretinoin
  • Sequence Homology, Amino Acid
  • Receptors, Natural Killer Cell
  • Receptors, Immunologic
  • Receptors, Antigen, T-Cell
  • RNA, Messenger
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • NK Cell Lectin-Like Receptor Subfamily K