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Barriers and Opportunities for CAR T-Cell Targeting of Solid Tumors.

Publication ,  Journal Article
Conejo-Garcia, JR; Guevara-Patino, JA
Published in: Immunol Invest
November 2022

CAR T-cell therapy has transformed the treatment of hematological malignancies of the B cell lineage. However, the quest to fulfil the same promise for solid tumors is still in its infancy. This review summarizes some of the challenges that the field is trying to overcome for effective treatment of human carcinomas, including tumor heterogeneity, the paucity of truly tumor-specific targets, immunosuppression and metabolic restrictions at solid tumor beds, and defective T-cell trafficking. All these barriers are being currently investigated and, in some cases, targeted, by multiple independent groups. With clinical interventions against multiple human malignancies and different platforms under accelerated clinical development, the next few years will see an array of cellular therapies, including CAR T-cells, progressively becoming routine interventions to eliminate currently incurable diseases, as it happened with some hematological malignancies.

Duke Scholars

Published In

Immunol Invest

DOI

EISSN

1532-4311

Publication Date

November 2022

Volume

51

Issue

8

Start / End Page

2215 / 2225

Location

England

Related Subject Headings

  • Tumor Microenvironment
  • T-Lymphocytes
  • Receptors, Chimeric Antigen
  • Neoplasms
  • Immunotherapy, Adoptive
  • Immunology
  • Humans
  • Hematologic Neoplasms
  • 3204 Immunology
  • 1107 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Conejo-Garcia, J. R., & Guevara-Patino, J. A. (2022). Barriers and Opportunities for CAR T-Cell Targeting of Solid Tumors. Immunol Invest, 51(8), 2215–2225. https://doi.org/10.1080/08820139.2022.2096463
Conejo-Garcia, Jose R., and Jose A. Guevara-Patino. “Barriers and Opportunities for CAR T-Cell Targeting of Solid Tumors.Immunol Invest 51, no. 8 (November 2022): 2215–25. https://doi.org/10.1080/08820139.2022.2096463.
Conejo-Garcia JR, Guevara-Patino JA. Barriers and Opportunities for CAR T-Cell Targeting of Solid Tumors. Immunol Invest. 2022 Nov;51(8):2215–25.
Conejo-Garcia, Jose R., and Jose A. Guevara-Patino. “Barriers and Opportunities for CAR T-Cell Targeting of Solid Tumors.Immunol Invest, vol. 51, no. 8, Nov. 2022, pp. 2215–25. Pubmed, doi:10.1080/08820139.2022.2096463.
Conejo-Garcia JR, Guevara-Patino JA. Barriers and Opportunities for CAR T-Cell Targeting of Solid Tumors. Immunol Invest. 2022 Nov;51(8):2215–2225.

Published In

Immunol Invest

DOI

EISSN

1532-4311

Publication Date

November 2022

Volume

51

Issue

8

Start / End Page

2215 / 2225

Location

England

Related Subject Headings

  • Tumor Microenvironment
  • T-Lymphocytes
  • Receptors, Chimeric Antigen
  • Neoplasms
  • Immunotherapy, Adoptive
  • Immunology
  • Humans
  • Hematologic Neoplasms
  • 3204 Immunology
  • 1107 Immunology