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Lifetime Exposure to Cigarette Smoke and Risk of Ovarian Cancer by T-cell Tumor Immune Infiltration.

Publication ,  Journal Article
Hathaway, CA; Wang, T; Townsend, MK; Vinci, C; Jake-Schoffman, DE; Saeed-Vafa, D; Moran Segura, C; Nguyen, JV; Conejo-Garcia, JR; Fridley, BL ...
Published in: Cancer Epidemiol Biomarkers Prev
January 9, 2023

BACKGROUND: Exposure to cigarette smoke, particularly in early life, is modestly associated with ovarian cancer risk and may impact systemic immunity and the tumor immune response. However, no studies have evaluated whether cigarette smoke exposure impacts the ovarian tumor immune microenvironment. METHODS: Participants in the Nurses' Health Study (NHS) and NHSII reported on early life exposure to cigarette smoke and personal smoking history on questionnaires (n = 165,760). Multiplex immunofluorescence assays were used to measure markers of T cells and immune checkpoints in tumor tissue from 385 incident ovarian cancer cases. We used Cox proportional hazards models to evaluate HRs and 95% confidence intervals (CI) for developing ovarian tumors with a low (

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Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

January 9, 2023

Volume

32

Issue

1

Start / End Page

66 / 73

Location

United States

Related Subject Headings

  • Tumor Microenvironment
  • T-Lymphocytes
  • Risk
  • Ovarian Neoplasms
  • Humans
  • Female
  • Epidemiology
  • Cigarette Smoking
  • Adult
  • 42 Health sciences
 

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Hathaway, C. A., Wang, T., Townsend, M. K., Vinci, C., Jake-Schoffman, D. E., Saeed-Vafa, D., … Tworoger, S. S. (2023). Lifetime Exposure to Cigarette Smoke and Risk of Ovarian Cancer by T-cell Tumor Immune Infiltration. Cancer Epidemiol Biomarkers Prev, 32(1), 66–73. https://doi.org/10.1158/1055-9965.EPI-22-0877
Hathaway, Cassandra A., Tianyi Wang, Mary K. Townsend, Christine Vinci, Danielle E. Jake-Schoffman, Daryoush Saeed-Vafa, Carlos Moran Segura, et al. “Lifetime Exposure to Cigarette Smoke and Risk of Ovarian Cancer by T-cell Tumor Immune Infiltration.Cancer Epidemiol Biomarkers Prev 32, no. 1 (January 9, 2023): 66–73. https://doi.org/10.1158/1055-9965.EPI-22-0877.
Hathaway CA, Wang T, Townsend MK, Vinci C, Jake-Schoffman DE, Saeed-Vafa D, et al. Lifetime Exposure to Cigarette Smoke and Risk of Ovarian Cancer by T-cell Tumor Immune Infiltration. Cancer Epidemiol Biomarkers Prev. 2023 Jan 9;32(1):66–73.
Hathaway, Cassandra A., et al. “Lifetime Exposure to Cigarette Smoke and Risk of Ovarian Cancer by T-cell Tumor Immune Infiltration.Cancer Epidemiol Biomarkers Prev, vol. 32, no. 1, Jan. 2023, pp. 66–73. Pubmed, doi:10.1158/1055-9965.EPI-22-0877.
Hathaway CA, Wang T, Townsend MK, Vinci C, Jake-Schoffman DE, Saeed-Vafa D, Moran Segura C, Nguyen JV, Conejo-Garcia JR, Fridley BL, Tworoger SS. Lifetime Exposure to Cigarette Smoke and Risk of Ovarian Cancer by T-cell Tumor Immune Infiltration. Cancer Epidemiol Biomarkers Prev. 2023 Jan 9;32(1):66–73.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

January 9, 2023

Volume

32

Issue

1

Start / End Page

66 / 73

Location

United States

Related Subject Headings

  • Tumor Microenvironment
  • T-Lymphocytes
  • Risk
  • Ovarian Neoplasms
  • Humans
  • Female
  • Epidemiology
  • Cigarette Smoking
  • Adult
  • 42 Health sciences