Skip to main content
Journal cover image

Neglected no more: B cell-mediated anti-tumor immunity.

Publication ,  Journal Article
Conejo-Garcia, JR; Biswas, S; Chaurio, R; Rodriguez, PC
Published in: Semin Immunol
January 2023

Immuno-oncology has traditionally focused on the cellular arm of the adaptive immune response, while attributing tumor-promoting activity to humoral responses in tumor-bearing hosts. This view stems from mouse models that do not necessarily recapitulate the antibody response process consistently observed in most human cancers. In recent years, the field has reconsidered the coordinated action of T and B cell responses in the context of anti-tumor immunity, as in any other immune response. Thus, recent studies in human cancer identify B cell responses with better outcome, typically in association with superior T cell responses. An area of particular interest is tertiary lymphoid structures, where germinal centers produce isotype switched antibodies and B cells and T lymphocytes interact with other immune cell types. The presence of these lymphoid structures is associated with better immunotherapeutic responses and remain poorly understood. Here, we discuss recent discoveries on how coordination between humoral and cellular responses is required for effective immune pressure against malignant progression, providing a perspective on the role of tertiary lymphoid structures and interventions to elicit their formation in unresectable tumors.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Semin Immunol

DOI

EISSN

1096-3618

Publication Date

January 2023

Volume

65

Start / End Page

101707

Location

England

Related Subject Headings

  • Tertiary Lymphoid Structures
  • T-Lymphocytes
  • Neoplasms
  • Mice
  • Immunology
  • Humans
  • B-Lymphocytes
  • Animals
  • Adaptive Immunity
  • 3204 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Conejo-Garcia, J. R., Biswas, S., Chaurio, R., & Rodriguez, P. C. (2023). Neglected no more: B cell-mediated anti-tumor immunity. Semin Immunol, 65, 101707. https://doi.org/10.1016/j.smim.2022.101707
Conejo-Garcia, Jose R., Subir Biswas, Ricardo Chaurio, and Paulo C. Rodriguez. “Neglected no more: B cell-mediated anti-tumor immunity.Semin Immunol 65 (January 2023): 101707. https://doi.org/10.1016/j.smim.2022.101707.
Conejo-Garcia JR, Biswas S, Chaurio R, Rodriguez PC. Neglected no more: B cell-mediated anti-tumor immunity. Semin Immunol. 2023 Jan;65:101707.
Conejo-Garcia, Jose R., et al. “Neglected no more: B cell-mediated anti-tumor immunity.Semin Immunol, vol. 65, Jan. 2023, p. 101707. Pubmed, doi:10.1016/j.smim.2022.101707.
Conejo-Garcia JR, Biswas S, Chaurio R, Rodriguez PC. Neglected no more: B cell-mediated anti-tumor immunity. Semin Immunol. 2023 Jan;65:101707.
Journal cover image

Published In

Semin Immunol

DOI

EISSN

1096-3618

Publication Date

January 2023

Volume

65

Start / End Page

101707

Location

England

Related Subject Headings

  • Tertiary Lymphoid Structures
  • T-Lymphocytes
  • Neoplasms
  • Mice
  • Immunology
  • Humans
  • B-Lymphocytes
  • Animals
  • Adaptive Immunity
  • 3204 Immunology