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Data from The Intersectionality between Race, Ethnicity, and Residential-Level Socioeconomic Status in Disparities of Head and Neck Cancer Outcomes: A SEER Study

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Karanth, SD; Akinyemiju, T; Walker, CJ; Yang, D; Migliorati, CA; Yoon, H-S; Hong, Y-R; Washington, CJ; Lattimore, C; Fredenburg, KM; Braithwaite, D
April 3, 2023

<div>AbstractBackground:<p>Head and neck cancer (HNC) mortality differs by race, ethnicity, and socioeconomic status (SES). However, it is unclear whether the relationship between race/ethnicity and HNC-specific mortality varies according to the residence-level SES.</p>Methods:<p>Data from the Surveillance Epidemiology and End Results database included participants with primary HNC between 2006 and 2017 (followed through 2018) to assess the joint association of race/ethnicity and census-tract level SES Yost-index groups (quintiles) with all-cause and HNC-specific mortalities. Relative survival rates at 1, 5, and 10 years were calculated. Multivariable Cox proportional hazard regression models estimated hazard-ratios and 95% confidence intervals for all-cause mortality, and Fine-Gray subdistribution hazard models for HNC-specific mortality. Cumulative incidence curves for HNC-specific deaths were estimated.</p>Results:<p>76,095 patients were included in the analysis: 63.2% were <65 years, 73.4% male, and 11.3% non-Hispanic (NH) Black. Most patients (58.3%) were diagnosed at regional or distant stages and 20.6% died of HNC. The five-year relative survival rate increased with SES group, with 51.6% in the lowest SES group, and 74.1% in the highest SES group. NH-Black patients had higher risk of all-cause and HNC-specific mortality than NH-White patients, regardless of the SES group. NH-Asian/Pacific Islander and Hispanic patients had higher risk of HNC-specific mortality in some SES groups.</p>Conclusions:<p>NH-Black patients of all SES strata had significantly worse outcomes. Other factors, such as healthcare quality, may be associated with persistent disparities.</p>Impact:<p>The study highlights the persistence of significant racial disparities in HNC survival across socioeconomic categories. There is need to consider additional factors underlying these disparities.</p></div>

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Publication Date

April 3, 2023
 

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Karanth, S. D., Akinyemiju, T., Walker, C. J., Yang, D., Migliorati, C. A., Yoon, H.-S., … Braithwaite, D. (2023). Data from The Intersectionality between Race, Ethnicity, and Residential-Level Socioeconomic Status in Disparities of Head and Neck Cancer Outcomes: A SEER Study. https://doi.org/10.1158/1055-9965.c.6534627.v1
Karanth, Shama D., Tomi Akinyemiju, Courtney J. Walker, Danting Yang, Cesar A. Migliorati, Hyung-Suk Yoon, Young-Rock Hong, et al. “Data from The Intersectionality between Race, Ethnicity, and Residential-Level Socioeconomic Status in Disparities of Head and Neck Cancer Outcomes: A SEER Study,” April 3, 2023. https://doi.org/10.1158/1055-9965.c.6534627.v1.
Karanth SD, Akinyemiju T, Walker CJ, Yang D, Migliorati CA, Yoon H-S, Hong Y-R, Washington CJ, Lattimore C, Fredenburg KM, Braithwaite D. Data from The Intersectionality between Race, Ethnicity, and Residential-Level Socioeconomic Status in Disparities of Head and Neck Cancer Outcomes: A SEER Study. 2023.

DOI

Publication Date

April 3, 2023